Evidence map›Paper›PMID 35265656›Full record

ArticleFrontiers in nutrition2022

Association Between Blood Biochemical Factors Contributing to Cognitive Decline and B Vitamins in Patients With Alzheimer's Disease.

Ting Qian, Lei Zhao, Xiaoli Pan, Shaoming Sang, Yangqi Xu, Changpeng Wang, Chunjiu Zhong, Guoqiang Fei, Xiaoqin Cheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Observational
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Ting QianDepartment of Neurology, Zhongshan Hospital (Xiamen Branch), Fudan University, Shanghai, China.
Lei ZhaoDepartment of Neurology, Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Xiaoli PanDepartment of Neurology, Zhongshan Hospital (Xiamen Branch), Fudan University, Shanghai, China.
Shaoming SangDepartment of Neurology, Zhongshan Hospital (Xiamen Branch), Fudan University, Shanghai, China.
Yangqi XuDepartment of Neurology, Zhongshan Hospital (Xiamen Branch), Fudan University, Shanghai, China.
Changpeng WangDepartment of Neurology, Zhongshan Hospital (Xiamen Branch), Fudan University, Shanghai, China.
Chunjiu ZhongDepartment of Neurology, Zhongshan Hospital (Xiamen Branch), Fudan University, Shanghai, China.
Guoqiang FeiDepartment of Neurology, Zhongshan Hospital (Xiamen Branch), Fudan University, Shanghai, China.
Xiaoqin ChengDepartment of Neurology, Zhongshan Hospital (Xiamen Branch), Fudan University, Shanghai, China.
Fudan University · CNZhongshan Hospital · CNShanghai Ninth People's Hospital · CNState Key Laboratory of Medical Neurobiology

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Malnutrition, metabolism stress, inflammation, peripheral organs dysfunction, and B vitamins deficiency significantly contribute to the progression and mortality of Alzheimer's disease (AD). However, it is unclear which blood biochemical indicators are most closely related to cognitive decline and B vitamins deficiency (thiamine, folate, vitamin B12) in patients with AD. Methods: This was a cross-sectional study of 206 AD patients recruited from six hospitals in China. Thiamine diphosphate (TDP), the bioactive form of thiamine, was measured by high-performance liquid chromatography fluoroscopy (HPLC) at a single center. Levels of biochemical indicators (except TDP) were measured by regular and standard laboratory tests in each hospital. Pearson's rank correlation analysis was used to assess relationships between B vitamins and biochemical indicators. Results: Among the biochemical results, in AD population, malnutrition indicators (erythrocyte, hemoglobin, serum albumin, and total protein) were most significantly associated with cognitive function, as was free triiodothyronine (FT3) levels which had been observed in previous study. Malnutrition and FT3 levels depend on age but not apolipoprotein E (ApoE) genotype. Meanwhile, Among the B vitamins, TDP was the most significantly associated with malnutrition indicators and FT3. Conclusion: Our results indicated that TDP reduction could be a modifiable risk factor for malnutrition and FT3 that contributed to cognitive decline in AD patients. Correcting thiamine metabolism could serve as an optional therapy target for AD treatment.

Indexed as

Alzheimer's diseaseB vitaminscognitive dysfunctionmalnutritionTDP

Identifiers

PMID35265656
PMCPMC8898888
OpenAlexW4212786220

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.