Evidence map›Paper›PMID 35265628›Full record

ReviewFrontiers in cell and developmental biology2021

The Mechanosensory Role of Osteocytes and Implications for Bone Health and Disease States.

Jung Un Ally Choi, Amanda W Kijas, Jan Lauko, Alan E Rowan

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 1 pooled it
8.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.

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  19. Rethinking osteocyte modelsFrontiers in bioengineering and biotechnology · 2026
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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jung Un Ally ChoiAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, Australia.
Amanda W KijasAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, Australia.
Jan LaukoAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, Australia.
Alan E RowanAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, Australia.
University of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone homeostasis is a dynamic equilibrium between bone-forming osteoblasts and bone-resorbing osteoclasts. This process is primarily controlled by the most abundant and mechanosensitive bone cells, osteocytes, that reside individually, within chambers of porous hydroxyapatite bone matrix. Recent studies have unveiled additional functional roles for osteocytes in directly contributing to local matrix regulation as well as systemic roles through endocrine functions by communicating with distant organs such as the kidney. Osteocyte function is governed largely by both biochemical signaling and the mechanical stimuli exerted on bone. Mechanical stimulation is required to maintain bone health whilst aging and reduced level of loading are known to result in bone loss. To date, both

Indexed as

agingbone homeostasisbone therapeuticsintegrinsmechanotransductionosteocytesosteoporosissignaling pathway

Identifiers

PMID35265628
PMCPMC8900535
OpenAlexW4213390865

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.