Evidence map›Paper›PMID 35265621›Full record

ArticleFrontiers in cell and developmental biology2022

Long Non-Coding RNA PNKY Modulates the Development of Choroidal Neovascularization.

Lianjun Shi, Xue Han, Chang Liu, Xiumiao Li, Shuting Lu, Qin Jiang, Jin Yao

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Lianjun ShiThe Affiliated Eye Hospital, Nanjing Medical University, Nanjing, China.
Xue HanThe Affiliated Eye Hospital, Nanjing Medical University, Nanjing, China.
Chang LiuEye Institute, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Xiumiao LiThe Affiliated Eye Hospital, Nanjing Medical University, Nanjing, China.
Shuting LuThe Affiliated Eye Hospital, Nanjing Medical University, Nanjing, China.
Qin JiangThe Affiliated Eye Hospital, Nanjing Medical University, Nanjing, China.
Jin YaoThe Affiliated Eye Hospital, Nanjing Medical University, Nanjing, China.
Nanjing Medical University · CNSecond Affiliated Hospital of Nanjing Medical University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long non-coding RNAs (lncRNAs) have been widely implicated in human diseases. Our aim was to explore the regulatory role of changes in the expression levels of PNKY and its linked signaling networks in mediating stress-induced choroidal neovascularization. PNKY expression levels were reduced in mice by laser and exposure of endothelial cell to hypoxic stress. PNKY silencing exacerbated the formation of CNV in a laser-induced CNV model and an

Indexed as

choroidal neovascularizationlong non-coding RNAmiRNAPNKYpolypyrimidine bundle binding protein 1

Identifiers

PMID35265621
PMCPMC8899849
OpenAlexW4212818649

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.