Evidence map›Paper›PMID 35265595›Full record

ArticleFrontiers in bioengineering and biotechnology2022

Pleiotropic Effects of Simvastatin and Losartan in Preclinical Models of Post-Traumatic Elbow Contracture.

Michael A David, Alex J Reiter, Chelsey L Dunham, Ryan M Castile, James A Abraham, Leanne E Iannucci, Ishani D Shah, Necat Havlioglu, Aaron M Chamberlain, Spencer P Lake

Open access · goldAbstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Michael A DavidDepartment of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO, United States.
Alex J ReiterDepartment of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO, United States.
Chelsey L DunhamDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, United States.
Ryan M CastileDepartment of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO, United States.
James A AbrahamDepartment of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO, United States.
Leanne E IannucciDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, United States.
Ishani D ShahDepartment of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO, United States.
Necat HavliogluDepartment of Pathology, John Cochran VA Medical Center, St. Louis, MO, United States.
Aaron M ChamberlainDepartment of Orthopaedic Surgery, Washington University in St. Louis, St. Louis, MO, United States.
Spencer P LakeDepartment of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO, United States.
Washington University in St. Louis · USJohn Cochran VA Medical Center · US

Funding

Resource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2019 to 2026
$6.8M
Physical and Biological Treatment Strategies to Prevent Post-Traumatic Joint ContractureR01AR071444 · NIAMS · WASHINGTON UNIVERSITY · PI LAKE, SPENCER PARK · 2017 to 2022
$1.7M
NIAMS NIH HHS P30 AR074992NIAMS NIH HHS R01 AR071444
6 · The paper itself

Abstract

Elbow trauma can lead to post-traumatic joint contracture (PTJC), which is characterized by loss of motion associated with capsule/ligament fibrosis and cartilage damage. Unfortunately, current therapies are often unsuccessful or cause complications. This study aimed to determine the effects of prophylactically administered simvastatin (SV) and losartan (LS) in two preclinical models of elbow PTJC: an

Indexed as

gel contractionlosartanpost-traumatic joint contracturerat elbowsimvastatin

Identifiers

PMID35265595
PMCPMC8899197
OpenAlexW4212810750

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.