Evidence map›Paper›PMID 35265458›Full record

ArticleIDCases2022

Ampicillin plus ceftriaxone therapy against Enterococcus faecalis endocarditis: A case report, guidelines considerations, and literature review.

Andrea Marino, Antonio Munafò, Aldo Zagami, Manuela Ceccarelli, Edoardo Campanella, Federica Cosentino, Vittoria Moscatt, Giuseppina Cantarella, Rosaria Di Mauro, Renato Bernardini and 2 more

Registry-linked trialOpen access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in IDCases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05530837 (Characterization of Enterococcus Faecalis Endocarditis and Impact of Amoxicillin MIC Elevation on Patient Outcome), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05530837 completednot on this map

Characterization of Enterococcus Faecalis Endocarditis and Impact of Amoxicillin MIC Elevation on Patient Outcome

TypeobservationalSponsorFondation Hôpital Saint-JosephRan2022 to 2023Enrolled281ConditionsInfectious Endocarditis
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Restoring Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2024
    Article
  2. Restoring Ampicillin Sensitivity in Multidrug-ResistantJournal of microbiology and biotechnology · 2023
    Article
  3. A retrospective study ofJAC-antimicrobial resistance · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Andrea MarinoUnit of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Nesima Hospital, University of Catania, Catania, Italy.
Antonio MunafòDepartment of Biomedical and Biotechnological Science, School of Medicine, University of Catania, 95123 Catania, Italy.
Aldo ZagamiUnit of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Nesima Hospital, University of Catania, Catania, Italy.
Manuela CeccarelliUnit of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Nesima Hospital, University of Catania, Catania, Italy.
Edoardo CampanellaUnit of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Nesima Hospital, University of Catania, Catania, Italy.
Federica CosentinoUnit of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Nesima Hospital, University of Catania, Catania, Italy.
Vittoria MoscattUnit of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Nesima Hospital, University of Catania, Catania, Italy.
Giuseppina CantarellaDepartment of Biomedical and Biotechnological Science, School of Medicine, University of Catania, 95123 Catania, Italy.
Rosaria Di MauroDepartment of Biomedical and Biotechnological Science, School of Medicine, University of Catania, 95123 Catania, Italy.
Renato BernardiniDepartment of Biomedical and Biotechnological Science, School of Medicine, University of Catania, 95123 Catania, Italy.
Giuseppe NunnariUnit of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Bruno CacopardoUnit of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Nesima Hospital, University of Catania, Catania, Italy.
University of Catania · ITUniversity of Messina · ITOspedale Garibaldi · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Enterococcus faecalis infective endocarditis (EFIE) continues to be a very serious disease, showing considerable morbidity and mortality rates which are influenced by the spread of multi-drug resistant strains occurred in the last decades. Although aminoglycosides were considered the treatment of choice of EIFE, in recent years several studies have investigated alternative therapeutic approaches, including combinations of beta-lactams, mainly because of the aminoglycoside-renowned nephrotoxicity and the widespread development of high-level aminoglycosides resistance (HLAR). In this scenario, we reported a case involving a prosthetic valve infective endocarditis caused by an aminoglycoside-resistant E. faecalis strain which was successfully treated with ampicillin plus ceftriaxone despite the presence of artificial heart valve and the patient's severe clinical conditions.

Indexed as

Ampicillin plus ceftriaxoneAntibiotics resistanceDouble beta-lactams therapyEnterococcus faecalisInfective endocarditis

Identifiers

PMID35265458
PMCPMC8899221
OpenAlexW4214948034

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.