Evidence map›Paper›PMID 35265340›Full record

ArticleNational science review2022

Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy.

Hongjun Li, Zejun Wang, Edikan A Ogunnaike, Qing Wu, Guojun Chen, Quanyin Hu, Tianyuan Ci, Zhaowei Chen, Jinqiang Wang, Di Wen and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in National science review, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 1 pooled it
8.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 1 synthesis or guideline pooled it, 122 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. B7-H3 CAR T cells eradicate intrahepatic cholangiocarcinoma and induce durable response.Journal of experimental & clinical cancer research : CR · 2026
    Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Microneedle-Assisted Cell Delivery and Therapy.Research (Washington, D.C.) · 2026
    Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. [Biomaterials of different sizes for enhanced adoptive cell transfer therapy in solid tumors].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Hongjun LiCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Zejun WangDepartment of Bioengineering, University of California, Los Angeles, CA 90095, USA.
Edikan A OgunnaikeCenter for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.
Qing WuCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Guojun ChenDepartment of Bioengineering, University of California, Los Angeles, CA 90095, USA.
Quanyin HuJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA.
Tianyuan CiDepartment of Bioengineering, University of California, Los Angeles, CA 90095, USA.
Zhaowei ChenCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Jinqiang WangCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Di WenDepartment of Bioengineering, University of California, Los Angeles, CA 90095, USA.
Hongwei DuLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.ORCID https://orcid.org/0000-0002-7997-4507
Jie JiangDepartment of Cell Biology and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
Jie SunDepartment of Cell Biology and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
Xingcai ZhangJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.ORCID https://orcid.org/0000-0001-7114-1095
Gianpietro DottiLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
Zhen GuCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
California NanoSystems Institute · USUniversity of North Carolina at Chapel Hill · USFirst Affiliated Hospital Zhejiang University · CNHarvard University · USZhejiang University · CN

Funding

CAROLINA CANCER NANOTECHNOLOGY TRAINING PROGRAM (C-CNTP)T32CA196589 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Gaorav P. Gupta, ALEXANDER V KABANOV · 2015 to 2026
$4.5M
Platelets-Mediated Delivery of Checkpoint Inhibitors for Post-Surgical Cancer ImmunotherapyR01CA234343 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LI, SONG · 2019 to 2023
$2.0M
NCI NIH HHS R01 CA234343NCI NIH HHS T32 CA196589
6 · The paper itself

Abstract

Chimeric antigen receptor T cell (CAR T) therapy was a milestone in the treatment of relapsed and refractory B cell malignancies. However, beneficial effects of CAR T cells have not been obtained in solid tumors yet. Herein, we implement a porous microneedle patch that accommodates CAR T cells and allows

Indexed as

CAR T therapycell deliverydrug deliverymicroneedle patchsolid tumor treatment

Identifiers

PMID35265340
PMCPMC8900686
OpenAlexW3200832301

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.