Evidence map›Paper›PMID 35265205›Full record

ArticleTheranostics2022

Multi-modal molecular imaging maps the correlation between tumor microenvironments and nanomedicine distribution.

Nicole Strittmatter, Jennifer I Moss, Alan M Race, Daniel Sutton, Jaime Rodriguez Canales, Stephanie Ling, Edmond Wong, Joanne Wilson, Aaron Smith, Colin Howes and 4 more

Abstract read
In one paragraph

Article in Theranostics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Nicole StrittmatterImaging and Data Analytics, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Cambridge, UK.
Jennifer I MossBioscience, Discovery, Oncology R&D, AstraZeneca, Cambridge, UK.
Alan M RaceInstitute of Medical Bioinformatics and Biostatistics, University of Marburg, Germany.
Daniel SuttonImaging and Data Analytics, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Cambridge, UK.
Jaime Rodriguez CanalesTranslational Pathology & Biomarker Analysis, Translational Medicine, R&D Oncology, AstraZeneca, Gaithersburg, MD, USA.
Stephanie LingImaging and Data Analytics, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Cambridge, UK.
Edmond WongAntibody Discovery and Protein Engineering (ADPE), R&D, AstraZeneca, Cambridge, UK.
Joanne WilsonDMPK, Oncology R&D, AstraZeneca, Cambridge, UK.
Aaron SmithDMPK, Oncology R&D, AstraZeneca, Cambridge, UK.
Colin HowesDMPK, Oncology R&D, AstraZeneca, Cambridge, UK.
Josephine BunchNational Centre of Excellence in Mass Spectrometry Imaging (NiCE-MSI), National Physical Laboratory, Teddington, UK.
Simon T BarryBioscience, Discovery, Oncology R&D, AstraZeneca, Cambridge, UK.
Richard J A GoodwinImaging and Data Analytics, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Cambridge, UK.
Marianne B AshfordAdvanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, Macclesfield UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gaining insight into the heterogeneity of nanoparticle drug distribution within tumors would improve both design and clinical translation of nanomedicines. There is little data showing the spatio-temporal behavior of nanomedicines in tissues as current methods are not able to provide a comprehensive view of the nanomedicine distribution, released drug or its effects in the context of a complex tissue microenvironment.

Indexed as

NanoparticlesNeoplasmsAnimalsDrug CarriersDrug Delivery SystemsMolecular ImagingNanomedicineTissue DistributionTumor MicroenvironmentDrug Carriersmass spectrometry imagingnanomedicinetumor distribution

Identifiers

PMID35265205
PMCPMC8899579

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.