Evidence map›Paper›PMID 35265081›Full record

ArticleFrontiers in immunology2022

Unspecific CTL Killing Is Enhanced by High Glucose

Wenjuan Yang, Andreas Denger, Caroline Diener, Frederic Küppers, Leticia Soriano-Baguet, Gertrud Schäfer, Archana K Yanamandra, Renping Zhao, Arne Knörck, Eva C Schwarz and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 3 countries.

Wenjuan YangBiophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), School of Medicine, Saarland University, Homburg, Germany.
Andreas DengerCenter for Bioinformatics, Saarland University, Saarbrücken, Germany.
Caroline DienerInstitute of Human Genetics, School of Medicine, Saarland University, Homburg, Germany.
Frederic KüppersInternal Medicine II, University Hospital Saarland, Homburg, Germany.
Leticia Soriano-BaguetExperimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Gertrud SchäferBiophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), School of Medicine, Saarland University, Homburg, Germany.
Archana K YanamandraBiophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), School of Medicine, Saarland University, Homburg, Germany.
Renping ZhaoBiophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), School of Medicine, Saarland University, Homburg, Germany.
Arne KnörckBiophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), School of Medicine, Saarland University, Homburg, Germany.
Eva C SchwarzBiophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), School of Medicine, Saarland University, Homburg, Germany.
Martin HartInstitute of Human Genetics, School of Medicine, Saarland University, Homburg, Germany.
Frank LammertInternal Medicine II, University Hospital Saarland, Homburg, Germany.
Leticia Prates RomaBiophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), School of Medicine, Saarland University, Homburg, Germany.
Dirk BrennerExperimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Grigorios ChristidisInternal Medicine II, University Hospital Saarland, Homburg, Germany.
Volkhard HelmsCenter for Bioinformatics, Saarland University, Saarbrücken, Germany.
Eckart MeeseInstitute of Human Genetics, School of Medicine, Saarland University, Homburg, Germany.
Markus HothBiophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), School of Medicine, Saarland University, Homburg, Germany.
Bin QuBiophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), School of Medicine, Saarland University, Homburg, Germany.
Saarland University · DEUniversity of Luxembourg · LUUniversity of Southern Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

TNF-related apoptosis inducing ligand (TRAIL) is expressed on cytotoxic T lymphocytes (CTLs) and TRAIL is linked to progression of diabetes. However, the impact of high glucose on TRAIL expression and its related killing function in CTLs still remains largely elusive. Here, we report that TRAIL is substantially up-regulated in CTLs in environments with high glucose (HG) both

Indexed as

T-Lymphocytes, CytotoxicTNF-Related Apoptosis-Inducing LigandGlucosePhosphatidylinositol 3-KinasesReceptors, TNF-Related Apoptosis-Inducing LigandGlucosePhosphatidylinositol 3-KinasesReceptors, TNF-Related Apoptosis-Inducing LigandTNF-Related Apoptosis-Inducing LigandCTLsHigh glucosePI3K-Akt, NFκBROSTRAIL

Identifiers

PMID35265081
PMCPMC8899024
OpenAlexW4212790691

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.