ArticleNature2022
Tryptophan depletion results in tryptophan-to-phenylalanine substitutants.
Erratum issuedOpen access · hybridAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 88 papers.
0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed
8.0field-weighted citation impact, top 1% of its field
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
88 citing papers in PubMed, 129 citations in OpenAlex.
- pXg: Comprehensive and Reliable Identification of MHC-I Antigens Using De Novo Peptide Sequencing and Immunotranscriptomic Datasets.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Mapping the functional dark proteome in cancer.Nature reviews. Cancer · 2026Review
- Global and specific mechanisms stimulate mistranslation in cancer.Nature cell biology · 2026Article
- Recoding by NNature communications · 2026Article
- Review
- Compensatory pathways in tryptophan metabolism and immune regulation following IDO inhibition.Molecular biology reports · 2026Review
- Palladium-triggered bioorthogonal phenylalanine decaging.Nature chemistry · 2026Article
- Tryptophan metabolism in tumor microenvironment and therapeutic implications.Journal of advanced research · 2026Review
- Nuclear localization of the glutaminyl-tRNA synthetase QARS reveals its role in DNA damage response in ovarian cancer.Nature communications · 2026Article
- Arginine Deprivation of ASS1-Deficient Cancers Drives Mistranslation and Shared Neoepitope Production.Cancer research · 2026Article
- Human aminoacyl-tRNA synthetases as integrators of translation and cell signalling networks.Nature reviews. Molecular cell biology · 2026Review
- Histidine to glutamine substitutants, a regulated process that impacts cell survival and suggests histidine shortage in cancer.Cell death discovery · 2026Article
- Review
- Identification of non-canonical peptides with moPepGen.Nature biotechnology · 2026Article
- Metabolic permissiveness: how tissue context shapes cancer.Genes & development · 2026Review
- Targeting Tryptophan Metabolism for Tuberculosis Biomarkers and Host-Directed Therapy.The Journal of infectious diseases · 2026Review
- Assessing the Performance of Mass Spectrometry Search Strategies in Identifying Translational Errors Using PDX Proteomics Data.Molecular & cellular proteomics : MCP · 2026Article
- PRMT3 Drives IDO1-Dependent Radioresistance and Immunosuppression by Promoting Kynurenine Metabolism in Non-Small Cell Lung Cancer.Cancer research · 2026Article
- Ribosome-associated quality control of aberrant protein production during amino acid limitation.bioRxiv : the preprint server for biology · 2026Article
- A systematic characterization of amino acid metabolism-related genes reveals molecular subtypes and a prognostic signature in bladder cancer.Frontiers in oncology · 2026Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
24 authors at 6 institutions in 4 countries.
Abhijeet Pataskar *Division of Oncogenomics, Oncode institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Julien Champagne *Division of Oncogenomics, Oncode institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0001-8460-858X
Remco Nagel *Division of Oncogenomics, Oncode institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Juliana KenskiDivision of Molecular Oncology and Immunology, Oncode institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Maarja LaosDepartment of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway.
Justine MichauxLausanne Branch, Ludwig Institute for Cancer Research, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Hui Song PakLausanne Branch, Ludwig Institute for Cancer Research, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Onno B BleijerveldNKI Proteomics facility, The Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-9395-2347
Kelly MordenteDivision of Oncogenomics, Oncode institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Jasmine Montenegro NavarroDivision of Oncogenomics, Oncode institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Naomi BlommaertDivision of Oncogenomics, Oncode institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Morten M NielsenDepartment of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway.
Domenica LovecchioDivision of Oncogenomics, Oncode institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-6297-8384
Everett StoneDepartment of Molecular Biosciences, University of Texas, Austin, TX, USA.
George GeorgiouDepartment of Molecular Biosciences, University of Texas, Austin, TX, USA.ORCID http://orcid.org/0000-0002-8823-3073
Mark C de GooijerDivision of Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-2812-991X
Olaf van TellingenDivision of Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-1037-6269
Maarten AltelaarNKI Proteomics facility, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Robbie P JoostenDivision of Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-2323-2686
Anastassis PerrakisDivision of Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-1151-6227
Johanna OlweusDepartment of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway.ORCID http://orcid.org/0000-0002-1898-3100
Michal Bassani-SternbergLausanne Branch, Ludwig Institute for Cancer Research, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-1934-954X
Daniel S PeeperDivision of Molecular Oncology and Immunology, Oncode institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0003-1293-3177
Reuven AgamiDivision of Oncogenomics, Oncode institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands. r.agami@nki.nl.ORCID http://orcid.org/0000-0002-2848-2473
The Netherlands Cancer Institute · NLLudwig Cancer Research · CHOslo University Hospital · NOThe University of Texas at Austin · USErasmus MC · NLUtrecht University · NL
Funding
European Research Council
Abstract
Activated T cells secrete interferon-γ, which triggers intracellular tryptophan shortage by upregulating the indoleamine 2,3-dioxygenase 1 (IDO1) enzyme
Indexed as
TryptophanTryptophan-tRNA LigaseCodonIndoleamine-Pyrrole 2,3,-DioxygenaseInterferon-gammaNeoplasmsPhenylalanineT-LymphocytesTryptophan OxygenaseCodonIndoleamine-Pyrrole 2,3,-DioxygenaseInterferon-gammaPhenylalanineTryptophanTryptophan OxygenaseTryptophan-tRNA Ligase
Identifiers
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.