ArticleCommunications biology2022
Non-invasive human skin transcriptome analysis using mRNA in skin surface lipids.
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Effects of diacylglycerol-enriched alpha-linolenic acid oil on skin properties in mild skin discomfort: a randomized, double-blind, placebo-controlled study.Scientific reports · 2026Trial
- Cell Death by Holocrine Secretion: The Final Step of Epithelial Differentiation in Sebaceous Glands.Cells · 2026Review
- Comparative Transcriptomics Suggests that Breast Secretory Epithelium Reuses Gene Repertoires Conserved Across Vertebrates Beyond Mammals.Genome biology and evolution · 2026Article
- Transcriptomic Profiling of Psoriatic Lesions by Tape-Stripping Reveals Site-Specific Differences.Journal of clinical medicine · 2026Article
- Development of a non-invasive diagnostic method for pathogenic RNA viruses using sebum wiped from the cat's body surface.Scientific reports · 2026Article
- The Sebaceous Gland: A Key Player in the Balance Between Homeostasis and Inflammatory Skin Diseases.Cells · 2025Review
- Non-invasive SARS-CoV-2 RNA detection and human transcriptome analysis using skin surface lipids.Scientific reports · 2024Article
- Impact of Dupilumab on Skin Surface Lipid-RNA Profile in Severe Asthmatic Patients.Current issues in molecular biology · 2024Article
- Skin Development and Disease: A Molecular Perspective.Current issues in molecular biology · 2024Review
- Skin single-cell transcriptomics reveals a core of sebaceous gland-relevant genes shared by mice and humans.BMC genomics · 2024Article
- Stratum corneum nanotexture feature detection using deep learning and spatial analysis: a noninvasive tool for skin barrier assessment.GigaScience · 2024Article
- Skin Surface Lipid-RNA Profile Obtained from Patients with Severe Asthma After Benralizumab Treatment.Journal of asthma and allergy · 2024Article
- Assessment of Treatment-Relevant Immune Biomarkers in Psoriasis and Atopic Dermatitis: Toward Personalized Medicine in Dermatology.The Journal of investigative dermatology · 2023Review
- Assessment of Multidimensional Health Care Parameters Among Adults in Japan for Developing a Virtual Human Generative Model: Protocol for a Cross-sectional Study.JMIR research protocols · 2023Article
- Non-invasive transcriptomic analysis using mRNAs in skin surface lipids obtained from children with mild-to-moderate atopic dermatitis.Journal of the European Academy of Dermatology and Venereology : JEADV · 2022Article
- Non-invasive diagnostic tool for Parkinson's disease by sebum RNA profile with machine learning.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-invasive acquisition of mRNA data from the skin can be extremely useful for understanding skin physiology and diseases. Inspired by the holocrine process, in which the sebaceous glands secrete cell contents into the sebum, we focused on the possible presence of mRNAs in skin surface lipids (SSLs). We found that measurable levels of human mRNAs exist in SSLs, where the sebum protects them from degradation by RNases. The AmpliSeq transcriptome analysis was modified to measure SSL-RNA levels, and our results revealed that the SSL-RNAs predominantly comprised mRNAs derived from sebaceous glands, the epidermis, and hair follicles. Analysis of SSL-RNAs non-invasively collected from patients with atopic dermatitis revealed increased expression of inflammation-related genes and decreased expression of terminal differentiation-related genes, consistent with the results of previous reports. Further, we found that lipid synthesis-related genes were downregulated in the sebaceous glands of patients with atopic dermatitis. These results indicate that the analysis of SSL-RNAs is a promising strategy to understand the pathophysiology of skin diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.