Evidence map›Paper›PMID 35264692›Full record

Trial reportScientific reports2022

Randomized clinical trial of streaming dichoptic movies versus patching for treatment of amblyopia in children aged 3 to 7 years.

Reed M Jost, Lindsey A Hudgins, Lori M Dao, David R Stager, Becky Luu, Cynthia L Beauchamp, Jeffrey S Hunter, Prashanthi Giridhar, Yi-Zhong Wang, Eileen E Birch

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Guideline
  5. Pooled it
  6. Guideline
  7. Pooled it
  8. Efficacy of patching combined with action video games in amblyopic children aged 4-10 years: A randomised clinical trial.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025
    Trial
  9. Patch-free streaming contrast-rebalanced dichoptic cartoons versus patching for treatment of amblyopia in children aged 3 to 5 years: a pilot, randomized clinical trial.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2024
    Trial
  10. Trial
  11. Factors associated with visual acuity improvement with a binocular digital therapeutic for amblyopia.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2023
    Trial
  12. Trial
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Baseline and outcome stereoacuity of children with anisometropic amblyopia undergoing dichoptic amblyopia treatment.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2025
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Reed M JostPediatric Vision Laboratory, Retina Foundation of the Southwest, 9600 North Central Expressway, Suite 200, Dallas, TX, 75231, USA.
Lindsey A HudginsPediatric Vision Laboratory, Retina Foundation of the Southwest, 9600 North Central Expressway, Suite 200, Dallas, TX, 75231, USA.
Lori M DaoABC Eyes - Pediatric Ophthalmology, Dallas, TX, USA.
David R StagerPediatric Ophthalmology & Adult Strabismus, Plano, TX, USA.
Becky LuuPediatric Ophthalmology & Adult Strabismus, Plano, TX, USA.
Cynthia L BeauchampABC Eyes - Pediatric Ophthalmology, Dallas, TX, USA.
Jeffrey S HunterHeaton Eye Associates, Tyler, TX, USA.
Prashanthi GiridharABC Eyes - Pediatric Ophthalmology, Dallas, TX, USA.
Yi-Zhong WangPediatric Vision Laboratory, Retina Foundation of the Southwest, 9600 North Central Expressway, Suite 200, Dallas, TX, 75231, USA.
Eileen E BirchPediatric Vision Laboratory, Retina Foundation of the Southwest, 9600 North Central Expressway, Suite 200, Dallas, TX, 75231, USA. ebirch@retinafoundation.org.

Funding

Binocular Vision, Amblyopia, and Refractive Development in EsotropiaR01EY022313 · NEI · RETINA FOUNDATION OF THE SOUTHWEST · PI Eileen Elizabeth Birch · 2012 to 2026
$7.0M
NEI NIH HHS R01 EY022313
6 · The paper itself

Abstract

Contrast-rebalanced dichoptic movies have been shown to be an effective binocular treatment for amblyopia in the laboratory. Yet, at-home therapy is a more practical approach. In a randomized clinical trial, we compared dichoptic movies, streamed at-home on a handheld 3D-enabled game console, versus patching as amblyopia treatment. Sixty-five amblyopic children (3-7 years; 20/32-125) were randomly assigned to one of two parallel arms, binocular treatment (3 movies/week) or patching (14 h/week). The primary outcome, change in best corrected visual acuity (BCVA) at the 2-week visit was completed by 28 and 30, respectively. After the primary outcome, both groups of children had the option to complete up to 6 weeks of binocular treatment. At the 2-week primary outcome visit, BCVA had improved in the movie (0.07 ± 0.02 logMAR; p < .001) and patching (0.06 ± 0.01 logMAR; p < 0.001) groups. There was no significant difference between groups (CI

Indexed as

AmblyopiaVideo GamesChildComputers, HandheldFollow-Up StudiesHumansMotion PicturesPyrimethamineSulfadiazineTreatment OutcomeVision, BinocularPyrimethamineSulfadiazine

Identifiers

PMID35264692
PMCPMC8905014

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.