Evidence map›Paper›PMID 35264559›Full record

ArticleNature communications2022

First-in-human immunoPET imaging of HIV-1 infection using

Denis R Beckford-Vera, Robert R Flavell, Youngho Seo, Enrique Martinez-Ortiz, Maya Aslam, Cassandra Thanh, Emily Fehrman, Marion Pardons, Shreya Kumar, Amelia N Deitchman and 20 more

Open access · goldAbstract readClinical Trial, Phase I
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Ultra-low dose immunoPET usingFrontiers in medicine · 2025
    Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Advances and challenges in immunoPET methodology.Frontiers in nuclear medicine · 2024
    Review
  18. Recent Advancements in Radiopharmaceuticals for Infection Imaging.Methods in molecular biology (Clifton, N.J.) · 2024
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 4 institutions in 2 countries.

Denis R Beckford-VeraDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Robert R FlavellDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-8694-1199
Youngho SeoDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-5908-6636
Enrique Martinez-OrtizDivision of HIV, Infectious Diseases and Global Medicine, University of California San Francisco, San Francisco, CA, USA.
Maya AslamDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Cassandra ThanhDivision of Experimental Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6458-3469
Emily FehrmanDivision of HIV, Infectious Diseases and Global Medicine, University of California San Francisco, San Francisco, CA, USA.
Marion PardonsDepartment of Microbiology, Infectiology and Immunology, Centre de Recherche du CHUM, Université de Montréal, Montreal, QC, Canada.
Shreya KumarDivision of Experimental Medicine, University of California San Francisco, San Francisco, CA, USA.
Amelia N DeitchmanDepartment of Clinical Pharmacy, University of California, San Francisco, USA.ORCID http://orcid.org/0000-0002-4722-463X
Vahid RavanfarDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Brailee SchulteDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
I-Wei Katherine WuDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Tony PanDivision of Experimental Medicine, University of California San Francisco, San Francisco, CA, USA.
Jacqueline D ReevesDivision of Experimental Medicine, University of California San Francisco, San Francisco, CA, USA.
Christopher C NixonDivision of Experimental Medicine, University of California San Francisco, San Francisco, CA, USA.
Nikita S IyerDivision of Experimental Medicine, University of California San Francisco, San Francisco, CA, USA.
Leonel TorresDivision of Experimental Medicine, University of California San Francisco, San Francisco, CA, USA.
Sadie E MunterDivision of Experimental Medicine, University of California San Francisco, San Francisco, CA, USA.
Tony HyunhDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Christos J PetropoulosMonogram Biosciences, Inc., Laboratory Corporation of America, South San Francisco, San Francisco, USA.ORCID http://orcid.org/0000-0001-5496-8090
Rebecca HohDivision of HIV, Infectious Diseases and Global Medicine, University of California San Francisco, San Francisco, CA, USA.
Benjamin L FrancDepartment of Radiology, Stanford University, Palo Alto, CA, USA.
Lucio GamaVaccine Research Center, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Richard A KoupVaccine Research Center, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
John R MascolaVaccine Research Center, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Nicolas ChomontDepartment of Microbiology, Infectiology and Immunology, Centre de Recherche du CHUM, Université de Montréal, Montreal, QC, Canada.ORCID http://orcid.org/0000-0001-9747-5018
Steven G DeeksDivision of HIV, Infectious Diseases and Global Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6371-747X
Henry F VanBrocklinDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA. Henry.Vanbrocklin@ucsf.edu.ORCID http://orcid.org/0000-0003-2849-0841
Timothy J HenrichDivision of Experimental Medicine, University of California San Francisco, San Francisco, CA, USA. Timothy.Henrich@ucsf.edu.ORCID http://orcid.org/0000-0002-6684-0622
University of California, San Francisco · USNational Institutes of Health · USCentre Hospitalier de l’Université de Montréal · CAPalo Alto University · US

Funding

Delaney AIDS Research Enterprise to Cure HIVUM1AI126611 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DEEKS, STEVEN GRANT, PICKER, LOUIS J. · 2016 to 2020
$27.9M
HIV/SIV Replication In VivoZIAAI005014 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI KOUP, RICHARD A · 2009 to 2025
$22.7M
In Vivo PET Imaging of HIV InfectionR01AI152932 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HENRICH, TIMOTHY JENSEN, HSUE, PRISCILLA Y. · 2020 to 2025
$3.7M
NIAID NIH HHS R01 AI152932NIAID NIH HHS UM1 AI126611
6 · The paper itself

Abstract

A major obstacle to achieving long-term antiretroviral (ART) free remission or functional cure of HIV infection is the presence of persistently infected cells that establish a long-lived viral reservoir. HIV largely resides in anatomical regions that are inaccessible to routine sampling, however, and non-invasive methods to understand the longitudinal tissue-wide burden of HIV persistence are urgently needed. Positron emission tomography (PET) imaging is a promising strategy to identify and characterize the tissue-wide burden of HIV. Here, we assess the efficacy of using immunoPET imaging to characterize HIV reservoirs and identify anatomical foci of persistent viral transcriptional activity using a radiolabeled HIV Env-specific broadly neutralizing antibody,

Indexed as

HIV-1HIV InfectionsAntibodies, NeutralizingBroadly Neutralizing AntibodiesCD4-Positive T-LymphocytesHumansPositron-Emission TomographyViral LoadViremiaAntibodies, NeutralizingBroadly Neutralizing Antibodies

Identifiers

PMID35264559
PMCPMC8907355
OpenAlexW4220836975

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.