Evidence map›Paper›PMID 35264460›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2022

CRISPR/Cas9-Mediated Insertion of HIV Long Terminal Repeat within

Michelle L Christian, Michael J Dapp, Samuel C Scharffenberger, Hank Jones, Chaozhong Song, Lisa M Frenkel, Anthony Krumm, James I Mullins, David J Rawlings

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. The STAT Signaling Pathway in HIV-1 Infection: Roles and Dysregulation.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Proviruses in CD4Science translational medicine · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Michelle L ChristianSeattle Children's Research Institute, Seattle, WA.
Michael J DappDepartment of Microbiology, University of Washington, School of Medicine, Seattle, WA.ORCID 0000-0003-3854-855X
Samuel C ScharffenbergerSeattle Children's Research Institute, Seattle, WA.ORCID 0000-0001-5905-8862
Hank JonesSeattle Children's Research Institute, Seattle, WA.
Chaozhong SongDepartment of Microbiology, University of Washington, School of Medicine, Seattle, WA.
Lisa M FrenkelSeattle Children's Research Institute, Seattle, WA.ORCID 0000-0001-9566-8959
Anthony KrummDepartment of Microbiology, University of Washington, School of Medicine, Seattle, WA.
James I MullinsDepartment of Microbiology, University of Washington, School of Medicine, Seattle, WA; drawling@uw.edu jmullins@uw.edu.
David J RawlingsSeattle Children's Research Institute, Seattle, WA; drawling@uw.edu jmullins@uw.edu.ORCID 0000-0002-0810-1776
University of Washington · US

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI EDWIN ROBERTO ORELLANA · 1988 to 2026
$104.9M
Modulating the Impact of Critical Events in Early HIV Infection: Effect of Early ART Initiation and Alcohol UseR01DA040532 · NIDA · FRED HUTCHINSON CANCER RESEARCH CENTER · PI DUERR, ANN C · 2015 to 2019
$8.0M
HIV integration-mediated modulation of immune regulation in HPV-associated cancersR01CA206466 · NCI · SEATTLE CHILDREN'S HOSPITAL · PI CASPER, COREY, FRENKEL, LISA M · 2016 to 2020
$5.5M
Defining HIV reservoirs that rebound following suspension of ARTR01AI134419 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI FRENKEL, LISA M, VANDEKERCKHOVE, LINOS · 2017 to 2021
$3.8M
Role of proviral loci in HIV latencyR01AI125026 · NIAID · UNIVERSITY OF WASHINGTON · PI MULLINS, JAMES IVAN · 2016 to 2019
$3.4M
Impact of Methamphetamine Use on the HIV Nucleome in Individuals on Antiretroviral TherapyR61DA047010 · NIDA · UNIVERSITY OF WASHINGTON · PI DUAN, ZHIJUN, MULLINS, JAMES IVAN · 2018 to 2020
$3.1M
Ex Vivo Detection and Analysis of Non-inducible Latent HIVR33AI122361 · NIAID · UNIVERSITY OF WASHINGTON · PI MULLINS, JAMES IVAN · 2018 to 2020
$1.6M
Ex Vivo Detection and Analysis of Non-inducible Latent HIVR21AI122361 · NIAID · UNIVERSITY OF WASHINGTON · PI MULLINS, JAMES IVAN · 2016 to 2017
$478k
NCI NIH HHS R01 CA206466NIAID NIH HHS P30 AI027757NIAID NIH HHS R01 AI125026NIAID NIH HHS R01 AI134419NIAID NIH HHS R21 AI122361NIAID NIH HHS R33 AI122361NIDA NIH HHS R01 DA040532NIDA NIH HHS R61 DA047010
6 · The paper itself

Abstract

One key barrier to curative therapies for HIV is the limited understanding of HIV persistence. HIV provirus integration sites (ISs) within

Indexed as

CRISPR-Cas SystemsHIV-1Basic-Leucine Zipper Transcription FactorsHIV Long Terminal RepeatHumansVirus IntegrationBACH2 protein, humanBasic-Leucine Zipper Transcription Factors

Identifiers

PMID35264460
PMCPMC8976747
OpenAlexW4220826553

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.