Evidence map›Paper›PMID 35264459›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2022

The Extracellular ATP Receptor P2RX7 Imprints a Promemory Transcriptional Signature in Effector CD8

Trupti Vardam-Kaur, Sarah van Dijk, Changwei Peng, Kelsey M Wanhainen, Stephen C Jameson, Henrique Borges da Silva

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. The ATP-exporting channel Pannexin-1 promotes CD8bioRxiv : the preprint server for biology · 2024
    Article
  8. Article
  9. Review
  10. Lung-resident CD69The Journal of allergy and clinical immunology · 2023
    Article
  11. The Role of IL-18 in P2RX7-Mediated Antitumor Immunity.International journal of molecular sciences · 2023
    Review
  12. Review
  13. Review
  14. The ART of tumor immune escape.Oncoimmunology · 2022
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Trupti Vardam-KaurDepartment of Immunology, Mayo Clinic Arizona, Scottsdale, AZ; and.ORCID 0000-0003-1458-1902
Sarah van DijkDepartment of Immunology, Mayo Clinic Arizona, Scottsdale, AZ; and.ORCID 0000-0002-7832-561X
Changwei PengCenter for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.ORCID 0000-0002-0710-9573
Kelsey M WanhainenCenter for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.
Stephen C JamesonCenter for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.ORCID 0000-0001-9137-1146
Henrique Borges da SilvaDepartment of Immunology, Mayo Clinic Arizona, Scottsdale, AZ; and borgesdasilva.henrique@mayo.edu.ORCID 0000-0001-9424-3326
Mayo Clinic in Arizona · USUniversity of Minnesota · US

Funding

T Cell HomeostasisR01AI038903 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI STEPHEN C JAMESON · 2001 to 2026
$5.9M
T cell homeostasisR37AI038903 · NIAID · UNIVERSITY OF MINNESOTA · PI JAMESON, STEPHEN C · 2006 to 2015
$3.6M
Regulation of T cell responses by P2RX7R01AI145147 · NIAID · UNIVERSITY OF MINNESOTA · PI JAMESON, STEPHEN C · 2019 to 2023
$3.3M
Control of antiviral memory CD8+ T cell longevity by extracellular ATP sensingR01AI170649 · NIAID · MAYO CLINIC ARIZONA · PI Henrique Borges da Silva · 2022 to 2026
$2.4M
DEFINING THE FUNCTION OF EXTRACELLULAR ATP SENSING FOR MEMORY CD8+ T CELL GENERATION AND LONGEVITYR00AI139381 · NIAID · MAYO CLINIC ARIZONA · PI BORGES DA SILVA, HENRIQUE · 2020 to 2021
$498k
MECHANISM AND ROLE OF T CELL RECEPTOR ANTAGONISMR29AI038903 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI JAMESON, STEPHEN C · 1996 to 2000
$111k
Defining the function of extracellular ATP sensing for memory CD8+ T cell generation and longevityK99AI139381 · NIAID · UNIVERSITY OF MINNESOTA · PI BORGES DA SILVA, HENRIQUE · 2019 to 2019
$100k
NIAID NIH HHS K99 AI139381NIAID NIH HHS R00 AI139381NIAID NIH HHS R01 AI038903NIAID NIH HHS R01 AI145147NIAID NIH HHS R01 AI170649NIAID NIH HHS R29 AI038903NIAID NIH HHS R37 AI038903
6 · The paper itself

Abstract

Development of CD8

Indexed as

CD8-Positive T-LymphocytesImmunologic MemoryAnimalsMiceMice, Inbred C57BLReceptors, Purinergic P2X7Transforming Growth Factor betaP2rx7 protein, mouseReceptors, Purinergic P2X7Transforming Growth Factor beta

Identifiers

PMID35264459
PMCPMC8976739
OpenAlexW4221063807

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.