ArticleCancer imaging : the official publication of the International Cancer Imaging Society2022
Endometrial carcinoma: use of tracer kinetic modeling of dynamic contrast-enhanced MRI for preoperative risk assessment.
Article in Cancer imaging : the official publication of the International Cancer Imaging Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 14 citations in OpenAlex.
- Preoperative risk assessment of endometrial cancer using histogram analysis of weighted and quantitative MRI images.Abdominal radiology (New York) · 2026Article
- Dynamic Contrast-Enhanced MRI in the Evaluation of Soft Tissue Tumors and Tumor-Like Lesions: Technical Principles and Clinical Applications.Korean journal of radiology · 2025Review
- Dynamic contrast‑enhanced MRI combined with intravoxel incoherent motion in quantitative evaluation for preoperative risk stratification of resectable rectal adenocarcinoma.Oncology letters · 2025Article
- Co-reactivity pattern of glucose metabolism and blood perfusion revealing DNA mismatch repair deficiency based on PET/DCE-MRI in endometrial cancer.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Article
- Evaluation of multi-parameter MRI in preoperative staging of endometrial carcinoma.European journal of radiology open · 2024Article
- Applying dynamic contrast-enhanced MRI tracer kinetic models to differentiate benign and malignant soft tissue tumors.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Article
- Dynamic contrast-enhanced MR imaging of uterine endometrial carcinoma with/without squamous differentiation.Abdominal radiology (New York) · 2023Article
- Quantitative dynamic contrast-enhanced parameters and intravoxel incoherent motion facilitate the prediction of TP53 status and risk stratification of early-stage endometrial carcinoma.Radiology and oncology · 2023Article
- Use of biexponential and stretched exponential models of intravoxel incoherent motion and dynamic contrast-enhanced magnetic resonance imaging to assess the proliferation of endometrial carcinoma.Quantitative imaging in medicine and surgery · 2023Article
- Tissue Characteristics of Endometrial Carcinoma Analyzed by Quantitative Synthetic MRI and Diffusion-Weighted Imaging.Diagnostics (Basel, Switzerland) · 2022Article
- Quantitative texture analysis based on dynamic contrast enhanced MRI for differential diagnosis between primary thymic lymphoma from thymic carcinoma.Scientific reports · 2022Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundTo compare two tracer kinetic models in predicting of preoperative risk types in endometrial carcinoma (EC) using DCE-MRI.
methodsA prospective study of patients with EC was conducted with institutional ethics approval and written informed consent. DCE-MRI data was analyzed using the extended Tofts (ET) and the distributed parameter (DP) models. DCE parameters blood flow (F), mean transit time, blood volume (Vp), extravascular extracellular volume (Ve), permeability surface area product (PS), extraction fraction, transfer constant (Ktrans), and efflux rate (Kep) between high- and low-risk EC were compared using the Mann-Whitney test. Bland-Altman analysis was utilized to compare parameter consistency and Spearman test to assess parameter correlation. Diagnostic performance of DCE parameters was analyzed by receiver-operating characteristic curve and compared with traditional MRI assessment.
resultsFifty-one patients comprised the study group. Patients with high-risk EC exhibited significantly lower Ktrans, Kep, F, Vp and PS (P < 0.001). ET-derived Ktrans and DP-derived F attained AUC of 0.92 and 0.91, respectively. Bland-Altman analysis showed that the consistency of Ve or Vp between the two models was low (P < 0.001) while Spearman test showed a strong correlation (r = 0.719, 0.871). Both Ktrans and F showed higher accuracy in predicting EC risk types than traditional MRI assessment.
conclusionsKinetic parameters derived from DCE-MRI revealed a more hypovascular microenvironment for high risk EC than to low- risk ones, providing potential imaging biomarkers in preoperative risk assessment that might improve individualized surgical planning and management of EC.
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