Evidence map›Paper›PMID 35264183›Full record

ReviewCell communication and signaling : CCS2022

The role of Staphylococcus aureus enterotoxin B in chronic rhinosinusitis with nasal polyposis.

Zahra Chegini, Mojtaba Didehdar, Amin Khoshbayan, Jafar Karami, Milad Yousefimashouf, Aref Shariati

Open access · goldAbstract readReviewVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell communication and signaling : CCS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 24 citations in OpenAlex.

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  10. Development and validation of a clinical risk prediction model for chronic sinusitis with nasal polyps: a retrospective analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Article
  11. [The role ofLin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Zahra CheginiDepartment of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Mojtaba DidehdarDepartment of Medical Parasitology and Mycology, Arak University of Medical Sciences, Arak, Iran.
Amin KhoshbayanDepartment of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Jafar KaramiMolecular and Medicine Research Center, Khomein University of Medical Sciences, Khomein, Iran.
Milad YousefimashoufDepartment of Medical Laboratory Sciences, Faculty of Paramedical, Borujerd Branch, Islamic Azad University, Borujerd, Iran.
Aref ShariatiMolecular and Medicine Research Center, Khomein University of Medical Sciences, Khomein, Iran. arefshariati0111@sbmu.ac.ir.ORCID 0000-0001-5860-1659
Imam Khomeini Hospital · IRArak University of Medical Sciences · IRHamedan University of Medical Sciences · IRIran University of Medical Sciences · IRIslamic Azad University Boroujerd Branch · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CRS with nasal polyps (CRSwNP) is a multifactorial disease, and various etiological factors like bacterial superantigens are known to develop this disease. Recent studies reported that Staphylococcus aureus nasal colonization was detected in 67% of the patients with CRSwNP. Moreover, it was reported that specific IgE against S. aureus enterotoxins are discovered in almost half of the nasal tissue homogenates from nasal polyps. Thus, investigations have highlighted the role of staphylococcal enterotoxins, especially enterotoxin B (SEB), in pathogenesis of CRSwNP. The destruction of mucosal integrity was reported as a main SEB-related pathogenic mechanisms in CRSwNP. SEB activates Toll Like Receptor 2 and triggers the production of pro-inflammatory cytokines; furthermore, it induces reactive oxygen species and endoplasmic reticulum stress-induced inflammation that may cause epithelial cell integrity disruption and enhance their permeability. SEB-induced Type 2/Th2 pathway results in degranulation of eosinophils, cationic proteins production, and localized eosinophilic inflammation. Furthermore, SEB may be involved in the expression of RORC and HIF-1α in Tregs and by maintaining the inflammation in sinonasal mucosa that could have a main role in the pathogenesis of nasal polyposis. Different in vitro findings were confirmed in animal studies; however, in vivo analysis of SEB-induced nasal polyps and CRS remains unfulfilled due to the lack of appropriate animal models. Finally, after elucidating different aspects of SEB pathogenesis in CRSwNP, therapeutic agents have been tested in recent studies with some encouraging results. The purpose of this article is to summarize the most important findings regarding SEB-induced CRS and nasal polyposis. Video Abstract.

Indexed as

Nasal PolypsRhinitisSinusitisAnimalsChronic DiseaseEnterotoxinsHumansInflammationStaphylococcus aureusEnterotoxinsChronic rhinosinusitisEnterotoxin BNasal polypsStaphylococcus aureusType 2/Th2 pathway

Identifiers

PMID35264183
PMCPMC8905720
OpenAlexW4220818658

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.