ArticleAmerican journal of human genetics2022
Predicted gene expression in ancestrally diverse populations leads to discovery of susceptibility loci for lifestyle and cardiometabolic traits.
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Article in American journal of human genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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8citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Multiomic integration analysis identifies atherogenic metabolites mediating between novel immune genes and cardiovascular risk.Genome medicine · 2024Pooled it
- Association between genetically predicted expression of TPMT and azathioprine adverse events.BMC pharmacology & toxicology · 2026Article
- The Eating Disorders Genetics Initiative 2 (EDGI2): study protocol.BMC psychiatry · 2025Article
- Implications of gene × environment interactions in post-traumatic stress disorder risk and treatment.The Journal of clinical investigation · 2025Review
- Allele frequency impacts the cross-ancestry portability of gene expression prediction in lymphoblastoid cell lines.American journal of human genetics · 2024Article
- Open Science Practices in Psychiatric Genetics: A Primer.Biological psychiatry global open science · 2024Review
- Associations of cardiometabolic polygenic risk scores with cardiovascular disease in African Americans.Research square · 2023Article
- What next for eating disorder genetics? Replacing myths with facts to sharpen our understanding.Molecular psychiatry · 2022Review
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Authors and funding
36 authors at 17 institutions in 1 country.
Heather M HighlandDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA. Electronic address: heather.highland@unc.edu.
Genevieve L WojcikDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Mariaelisa GraffDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
Katherine K NishimuraPublic Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Chani J HodonskyDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA; Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA.
Antoine R BaldassariDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
Alanna C CoteDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Iona ChengDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94143, USA.
Christopher R GignouxColorado Center for Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Ran TaoDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Yuqing LiDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94143, USA.
Eric BoerwinkleHuman Genetics Center, School of Public Health, The University of Texas Health Science Center, Houston, TX 77030, USA.
Myriam FornageHuman Genetics Center, School of Public Health, The University of Texas Health Science Center, Houston, TX 77030, USA; Brown Foundation Institute for Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center, Houston, TX 77030, USA.
Jeffrey HaesslerPublic Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Lucia A HindorffDivision of Genomic Medicine, NIH National Human Genome Research Institute, Bethesda, MD 20892, USA.
Yao HuPublic Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Anne E JusticeDepartment of Population Health Sciences, Geisinger Health System, Danville, PA 17822, USA.
Bridget M LinBiostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
Danyu LinBiostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
Daniel O StramPreventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Christopher A HaimanPreventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Charles KooperbergPublic Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; School of Public Health, University of Washington, Seattle, WA 98195, USA.
Loic Le MarchandUniversity of Hawaii, Honolulu, HI 96813, USA.
Tara C MatiseGenetics, Rutgers University, New Brunswick, NJ 08901-8554, USA.
Eimear E KennyInstitute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Christopher S CarlsonPublic Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Eli A StahlDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Christy L AveryDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
Kari E NorthDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
Jose Luis AmbiteInformation Sciences Institute, University of Southern California, Marina del Rey, CA 90292, USA.
Steven BuyskeStatistics, Rutgers University, New Brunswick, NJ 08901-8554, USA.
Ruth J LoosIcahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Ulrike PetersPublic Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; School of Public Health, University of Washington, Seattle, WA 98195, USA.
Kristin L YoungDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
Stephanie A BienPublic Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Laura M HuckinsDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Mental Illness Research, Education and Clinical Centers, James J. Peters Department of Veterans Affairs Medical Center, Bronx, NY 14068, USA. Electronic address: laura.huckins@mssm.edu.
University of North Carolina at Chapel Hill · USFred Hutch Cancer Center · USIcahn School of Medicine at Mount Sinai · USUniversity of Southern California · USRutgers, The State University of New Jersey · USUniversity of California, San Francisco · USUniversity of Washington · USBrown Foundation · USGeisinger Health System · USGenomic Health (United States) · USJames J. Peters VA Medical Center · USJohns Hopkins University · USNational Human Genome Research Institute · USThe University of Texas Health Science Center at Houston · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Hawaiʻi at Mānoa · USVanderbilt University Medical Center · US
Funding
Tissue Procurement & PathologyP50CA058223 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KATHERINE A. HOADLEY · 1992 to 2026
$59.3MWOMEN'S HEALTH INITIATIVE - CLINICAL COORDINATING CENTER: TASK AREA B - LONG LIFE STUDY VISIT 2 LIMITED HOME VISIT75N92021D00001 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ANDERSON, GARNET L. · 2021 to 2025
$52.0MTranslational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7MSouth Texas Alzheimer's Disease Research CenterP30AG066546 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Sudha Seshadri · 2021 to 2026
$24.0MA Center for GEI Association StudiesU01HG004424 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY · 2007 to 2010
$21.4MPolygenic Risk Scores for Diverse Populations - Bridging Research and Clinical CareR01HL151152 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Christy Leigh Avery, Jennifer Below · 2020 to 2026
$12.3MCardiovascular Epidemiology Training GrantT32HL007055 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Wayne D. Rosamond · 1986 to 2026
$10.0MEpidemiology of putative genuine genetic variant: The Women's Health IntiativeU01HG004790 · NHGRI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KOOPERBERG, CHARLES L · 2008 to 2012
$9.9MGenetic Epidemiology of Causal Variants Across the Life CourseU01HG004803 · NHGRI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NORTH, KARI E. · 2008 to 2012
$9.0MSTRONG HEART FAMILY STUDYU01HL065520 · NHLBI · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI COLE, SHELLEY A · 2000 to 2011
$8.9MLeveraging multi-omics approaches to examine metabolic challenges of obesity in relation to cardiovascular diseasesR01HL143885 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI AVERY, CHRISTY LEIGH, GORDON-LARSEN, PENNY · 2019 to 2022
$8.9MTRAINING PROGRAM IN MOLECULAR AND CELLULAR CARDIOLOGYT32HL007824 · NHLBI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI GELB, BRUCE D · 1995 to 2022
$8.6MMedical Research Council MC_PC_17228Medical Research Council MC_QA137853NCI NIH HHS P50 CA058223NHGRI NIH HHS L30 HG009840NHGRI NIH HHS R01 HG009974NHGRI NIH HHS R01 HG010297NHGRI NIH HHS R56 HG010297NHGRI NIH HHS U01 HG004424NHGRI NIH HHS U01 HG004446NHGRI NIH HHS U01 HG004729NHGRI NIH HHS U01 HG004790NHGRI NIH HHS U01 HG004801NHGRI NIH HHS U01 HG004802NHGRI NIH HHS U01 HG004803NHGRI NIH HHS U01 HG007376NHGRI NIH HHS U01 HG007397NHGRI NIH HHS U01 HG007416NHGRI NIH HHS U01 HG007417NHGRI NIH HHS U01 HG007419NHLBI NIH HHS 75N92021D00001NHLBI NIH HHS 75N92021D00002NHLBI NIH HHS K99 HL130580NHLBI NIH HHS R01 HL109301NHLBI NIH HHS R01 HL142302NHLBI NIH HHS R01 HL142825NHLBI NIH HHS R01 HL143885NHLBI NIH HHS R01 HL149683NHLBI NIH HHS R01 HL151152NHLBI NIH HHS R21 HL140419NHLBI NIH HHS T32 HL007055NHLBI NIH HHS T32 HL007824NHLBI NIH HHS T32 HL129982NHLBI NIH HHS U01 HL041652NHLBI NIH HHS U01 HL065520NHLBI NIH HHS U01 HL065521NIA NIH HHS P30 AG066546NIA NIH HHS U01 AG052409NICHD NIH HHS R01 HD057194NIDDK NIH HHS P30 DK020541NIDDK NIH HHS R01 DK122503NIH HHS S10 OD028685NIMH NIH HHS R01 MH118278WHI NIH HHS 75N92021D00003WHI NIH HHS 75N92021D00004WHI NIH HHS 75N92021D00005
Abstract
One mechanism by which genetic factors influence complex traits and diseases is altering gene expression. Direct measurement of gene expression in relevant tissues is rarely tenable; however, genetically regulated gene expression (GReX) can be estimated using prediction models derived from large multi-omic datasets. These approaches have led to the discovery of many gene-trait associations, but whether models derived from predominantly European ancestry (EA) reference panels can map novel associations in ancestrally diverse populations remains unclear. We applied PrediXcan to impute GReX in 51,520 ancestrally diverse Population Architecture using Genomics and Epidemiology (PAGE) participants (35% African American, 45% Hispanic/Latino, 10% Asian, and 7% Hawaiian) across 25 key cardiometabolic traits and relevant tissues to identify 102 novel associations. We then compared associations in PAGE to those in a random subset of 50,000 White British participants from UK Biobank (UKBB
Indexed as
Cardiovascular DiseasesGenome-Wide Association StudyGenetic Predisposition to DiseaseHumansLife StylePolymorphism, Single NucleotideTranscriptomePrediXcan, TWAS, ancestrally diverse, gene expression, cardiometabolic traits, PAGE
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