Evidence map›Paper›PMID 35263582›Full record

ArticleCell reports2022

Adrenergic C1 neurons monitor arterial blood pressure and determine the sympathetic response to hemorrhage.

George M P R Souza, Ruth L Stornetta, Daniel S Stornetta, Patrice G Guyenet, Stephen B G Abbott

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Noradrenaline Regulation of Brain-Body Communication.Advances in experimental medicine and biology · 2025
    Review
  7. Interactions between Arousal State and COThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  8. Article
  9. Adrenergic C1 neurons enhance anxiety via projections to PAG.bioRxiv : the preprint server for biology · 2024
    Article
  10. Molecular Organization of Autonomic, Respiratory, and Spinally-Projecting Neurons in the Mouse Ventrolateral Medulla.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  11. Article
  12. Molecular cell types as functional units of the efferent vagus nerve.Seminars in cell & developmental biology · 2024
    Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Chemogenetic activation of noradrenergic A5 neurons increases blood pressure and visceral sympathetic activity in adult rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

George M P R SouzaDepartment of Pharmacology, University of Virginia, 1340 Jefferson Park Avenue, Charlottesville, VA, USA.
Ruth L StornettaDepartment of Pharmacology, University of Virginia, 1340 Jefferson Park Avenue, Charlottesville, VA, USA.
Daniel S StornettaDepartment of Pharmacology, University of Virginia, 1340 Jefferson Park Avenue, Charlottesville, VA, USA.
Patrice G GuyenetDepartment of Pharmacology, University of Virginia, 1340 Jefferson Park Avenue, Charlottesville, VA, USA.
Stephen B G AbbottDepartment of Pharmacology, University of Virginia, 1340 Jefferson Park Avenue, Charlottesville, VA, USA. Electronic address: sba6t@virginia.edu.
University of Virginia · US

Funding

Retrotrapezoid nucleus and central chemoreceptionR01HL074011 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI GUYENET, PATRICE G. · 2003 to 2018
$6.6M
Organization of Central Sympathic PathwaysR01HL028785 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI STORNETTA, RUTH L · 1985 to 2020
$5.0M
ORGANIZATION OF CENTRAL SYMPATHETIC PATHWAYSR37HL028785 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI GUYENET, PATRICE G. · 1999 to 2008
$3.0M
Role of presympathetic neurons of the hindbrain in cardiovascular controlR01HL148004 · NHLBI · UNIVERSITY OF VIRGINIA · PI ABBOTT, STEPHEN · 2019 to 2023
$2.6M
NHLBI NIH HHS R01 HL028785NHLBI NIH HHS R01 HL074011NHLBI NIH HHS R01 HL148004NHLBI NIH HHS R37 HL028785
6 · The paper itself

Abstract

Hemorrhage initially triggers a rise in sympathetic nerve activity (SNA) that maintains blood pressure (BP); however, SNA is suppressed following severe blood loss causing hypotension. We hypothesized that adrenergic C1 neurons in the rostral ventrolateral medulla (C1

Indexed as

Adrenergic NeuronsHypotensionAdrenergic AgentsAnimalsArterial PressureBlood PressureHemorrhageMedulla OblongataRatsRats, Sprague-DawleySympathetic Nervous SystemAdrenergic Agentsautonomic nervous systemblood pressurecalcium imagingcardiovascular regulationfiber photometryGCaMPoptogeneticsRVLM

Identifiers

PMID35263582
PMCPMC8958877
OpenAlexW4220897889

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.