Evidence map›Paper›PMID 35263544›Full record

ArticleACS biomaterials science & engineering2022

Hydroxyapatite Pellets as Versatile Model Surfaces for Systematic Adhesion Studies on Enamel: A Force Spectroscopy Case Study.

Johannes Mischo, Thomas Faidt, Ryan B McMillan, Johanna Dudek, Gubesh Gunaratnam, Pardis Bayenat, Anne Holtsch, Christian Spengler, Frank Müller, Hendrik Hähl and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in ACS biomaterials science & engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Johannes MischoExperimental Physics and Center for Biophysics, Saarland University, 66123 Saarbrücken, Germany.ORCID 0000-0002-9668-6603
Thomas FaidtExperimental Physics and Center for Biophysics, Saarland University, 66123 Saarbrücken, Germany.ORCID 0000-0003-2035-786X
Ryan B McMillanExperimental Physics and Center for Biophysics, Saarland University, 66123 Saarbrücken, Germany.
Johanna DudekClinic of Operative Dentistry, Periodontology and Preventive Dentistry, Saarland University, 66421 Homburg/Saar, Germany.
Gubesh GunaratnamInstitute of Medical Microbiology and Hygiene and Center for Biophysics, Saarland University, 66421 Homburg/Saar, Germany.
Pardis BayenatExperimental Physics and Center for Biophysics, Saarland University, 66123 Saarbrücken, Germany.
Anne HoltschExperimental Physics and Center for Biophysics, Saarland University, 66123 Saarbrücken, Germany.ORCID 0000-0003-2454-593X
Christian SpenglerExperimental Physics and Center for Biophysics, Saarland University, 66123 Saarbrücken, Germany.ORCID 0000-0002-0504-1149
Frank MüllerExperimental Physics and Center for Biophysics, Saarland University, 66123 Saarbrücken, Germany.ORCID 0000-0001-8955-5317
Hendrik HählExperimental Physics and Center for Biophysics, Saarland University, 66123 Saarbrücken, Germany.ORCID 0000-0002-2708-0990
Markus BischoffInstitute of Medical Microbiology and Hygiene and Center for Biophysics, Saarland University, 66421 Homburg/Saar, Germany.ORCID 0000-0001-6734-2732
Matthias HannigClinic of Operative Dentistry, Periodontology and Preventive Dentistry, Saarland University, 66421 Homburg/Saar, Germany.
Karin JacobsExperimental Physics and Center for Biophysics, Saarland University, 66123 Saarbrücken, Germany.
Saarland University · DEInstitute of Medical Microbiology and Hygiene · DEMax Planck School Matter to Life

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Research into materials for medical application draws inspiration from naturally occurring or synthesized surfaces, just like many other research directions. For medical application of materials, particular attention has to be paid to biocompatibility, osseointegration, and bacterial adhesion behavior. To understand their properties and behavior, experimental studies with natural materials such as teeth are strongly required. The results, however, may be highly case-dependent because natural surfaces have the disadvantage of being subject to wide variations, for instance in their chemical composition, structure, morphology, roughness, and porosity. A synthetic surface which mimics enamel in its performance with respect to bacterial adhesion and biocompatibility would, therefore, facilitate systematic studies much better. In this study, we discuss the possibility of using hydroxyapatite (HAp) pellets to simulate the surfaces of teeth and show the possibility and limitations of using a model surface. We performed single-cell force spectroscopy with single

Indexed as

DurapatiteStaphylococcus aureusDental EnamelSpectrum AnalysisSurface PropertiesDurapatiteadhesionAFMblood plasmacontact angleellipsometryenamelhydroxyapatitesalivasingle-cell force spectroscopyStaphylococcus aureus

Identifiers

PMID35263544
PMCPMC9007113
OpenAlexW4220886725

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.