Evidence map›Paper›PMID 35263494›Full record

ArticleChembiochem : a European journal of chemical biology2022

Linkage-Specific Synthesis of Di-ubiquitin Probes Enabled by the Incorporation of Unnatural Amino Acid ThzK.

Han Zhou, Tomaya Carpenter, Xuan Fu, Bo Jin, Britton Ody, Mohammad Sazid Hassan, Savannah E Jacobs, Jenny Cheung, Eve M Nicholson, Mark Turlington and 4 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Internal Ubiquitin Electrophiles for Covalent Trapping and Inhibition of Deubiquitinases.Chembiochem : a European journal of chemical biology · 2025
    Article
  2. Article
  3. Review
  4. Reading and Writing the Ubiquitin Code Using Genetic Code Expansion.Chembiochem : a European journal of chemical biology · 2024
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Han ZhouDepartment of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USA.
Tomaya CarpenterDepartment of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USA.
Xuan FuDepartment of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USA.
Bo JinDepartment of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USA.
Britton OdyDepartment of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USA.
Mohammad Sazid HassanDepartment of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USA.
Savannah E JacobsDepartment of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USA.
Jenny CheungDepartment of Chemistry, Virginia Commonwealth University, Richmond, VA 23284, USA.
Eve M NicholsonDepartment of Chemistry, Virginia Commonwealth University, Richmond, VA 23284, USA.
Mark TurlingtonDepartment of Chemistry and Biochemistry, Berry College, Mount Berry, GA 30149, USA.
Bo ZhaoEngineering Research Center of Cell and Therapeutic Antibody, Ministry of Education, and School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
Sonja LorenzMax Planck Institute for Multidisciplinary Sciences, 37077, Göttingen, Germany.ORCID 0000-0002-9639-2381
T Ashton CroppDepartment of Chemistry, Virginia Commonwealth University, Richmond, VA 23284, USA.
Jun YinDepartment of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USA.ORCID 0000-0002-4803-7510
Georgia State University · USVirginia Commonwealth University · USBerry College · USMax Planck Institute for Multidisciplinary SciencesShanghai Jiao Tong University · CN

Funding

Orthogonal Ubiquitin Transfer to Profile E3 Substrate Specificity.R01GM104498 · NIGMS · UNIVERSITY OF CHICAGO · PI KIYOKAWA, HIROAKI, YIN, JUN · 2013 to 2021
$3.2M
Insights into Gordon Holmes syndrome by substrate profiling of Triad3A and Chip using Orthogonal Ubiquitin TransferR21NS116760 · NINDS · GEORGIA STATE UNIVERSITY · PI MABB, ANGELA M, YIN, JUN · 2021 to 2021
$429k
NIGMS NIH HHS R01 GM104498NINDS NIH HHS R21 NS116760
6 · The paper itself

Abstract

Di-ubiquitin (diUB) conjugates of defined linkages are useful tools for probing the functions of UB ligases, UB-binding proteins and deubiquitinating enzymes (DUBs) in coding, decoding and editing the signals carried by the UB chains. Here we developed an efficient method for linkage-specific synthesis of diUB probes based on the incorporation of the unnatural amino acid (UAA) N

Indexed as

Amino AcidsUbiquitinLysineUbiquitinationAmino AcidsLysineUbiquitindeubiquitinating enzymesexpressed protein ligationreactivity-based probesubiquitinunnatural amino acids

Identifiers

PMID35263494
PMCPMC9129888
OpenAlexW4220757442

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.