ArticleThe Plant cell2022
COP1 positively regulates ABA signaling during Arabidopsis seedling growth in darkness by mediating ABA-induced ABI5 accumulation.
Article in The Plant cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 68 citations in OpenAlex.
- COP1 regulates the abundance and stability of the Arabidopsis retromer protein AtVPS29 via the proteasome pathway.Plant signaling & behavior · 2026Article
- Uncovering the Secrets of How Plants Adapt to Water Stress.Plant, cell & environment · 2026Review
- RPT2a-mediated degradation of WDR5a regulates flowering time in Arabidopsis.Plant cell reports · 2026Article
- E3 ligase ATL17 is a key regulator of abscisic acid signaling that mediates AHG1 degradation in Arabidopsis thaliana.The New phytologist · 2026Article
- Nucleoporin Nup96 promotes plant photomorphogenesis by facilitating phyB photobody formation and HOS1-mediated PIF5 degradation in Arabidopsis.Plant communications · 2026Article
- SnRK2.6-mediated phosphorylation stabilizes proteasome regulator 1 (PTRE1) to enhance 26S proteasome activity and coordinate ABA signaling in Arabidopsis.Plant communications · 2026Article
- Constructing gene co-functional and co-regulatory networks from public transcriptomes using condition-specific ensemble co-expression.Nature communications · 2026Article
- Holistic overview of regulatory networks governing seed dormancy and germination in plants.Science China. Life sciences · 2026Review
- The COP1-ADA2b module mediates light regulation of DNA double-strand break repair in Arabidopsis.Nature communications · 2026Article
- Abscisic Acid and Calcium Signals Convergently Regulate Sugar Accumulation by Orchestrating the SRK2A/CIPK6-ABI5-TST2 Module in Citrus.Plant biotechnology journal · 2026Article
- ABI5-binding proteins are substrates of key components in the ABA core signaling pathway affecting seeds.Plant physiology · 2026Article
- Genome-wide identification and characterization of the Groucho/Tup1-like corepressor family identifies a potential role in the epigenetic regulation of abiotic stress responses in soybean.Frontiers in plant science · 2026Article
- The ADF4-RCAR12 module regulates ABA-mediated drought tolerance inFrontiers in plant science · 2026Article
- Light interacts with mechanical stress to regulate the seed-to-seedling transition.Stress biology · 2025Review
- QUIRKY controls seed germination via precision degradation of ABI5.Science advances · 2025Article
- A 14-3-3 modulator of seed weight and quality for unlocking the yield potential of soybean.Nature communications · 2025Article
- The PavDREB1E-PavD8-PavHY5 module integrates light and gibberellin signals to regulate sweet cherry anthocyanin biosynthesis.Plant physiology · 2025Article
- ODR1/AtSDR4L alleviates osmotic stress-induced germination arrest via ABA-dependent negative feedback on ABA biosynthesis.BMC plant biology · 2025Article
- CPK2 Enhances ABA Sensitivity in Seed Germination and Root Growth by Promoting ABA-InducedPlants (Basel, Switzerland) · 2025Article
- Identification of F-box proteins in ABA- and GA-regulated seed germination: interaction of GASA1 signalling peptide and ABA-induced ubiquitination.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CONSTITUTIVELY PHOTOMORPHOGENIC1 (COP1), a well-characterized E3 ubiquitin ligase, is a central repressor of seedling photomorphogenic development in darkness. However, whether COP1 is involved in modulating abscisic acid (ABA) signaling in darkness remains largely obscure. Here, we report that COP1 is a positive regulator of ABA signaling during Arabidopsis seedling growth in the dark. COP1 mediates ABA-induced accumulation of ABI5, a transcription factor playing a key role in ABA signaling, through transcriptional and post-translational regulatory mechanisms. We further show that COP1 physically interacts with ABA-hypersensitive DCAF1 (ABD1), a substrate receptor of the CUL4-DDB1 E3 ligase targeting ABI5 for degradation. Accordingly, COP1 directly ubiquitinates ABD1 in vitro, and negatively regulates ABD1 protein abundance in vivo in the dark but not in the light. Therefore, COP1 promotes ABI5 protein stability post-translationally in darkness by destabilizing ABD1 in response to ABA. Interestingly, we reveal that ABA induces the nuclear accumulation of COP1 in darkness, thus enhancing its activity in propagating the ABA signal. Together, our study uncovers that COP1 modulates ABA signaling during seedling growth in darkness by mediating ABA-induced ABI5 accumulation, demonstrating that plants adjust their ABA signaling mechanisms according to their light environment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.