Evidence map›Paper›PMID 35263271›Full record

ArticleNeurology2022

Disruptions of the Human Connectome Associated With Hemispatial Neglect.

Sadhvi Saxena, Zafer Keser, Chris Rorden, Leonardo Bonilha, Julius Fridriksson, Alexandra Walker, Argye Elizabeth Hillis

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sadhvi SaxenaFrom the Departments of Neurology (S.S., Z.K., A.W., A.E.H.) and Physical and Medicine & Rehabilitation (A.E.H.), Johns Hopkins University School of Medicine, Baltimore, MD; Departments of Psychology (C.R.) and Communication Sciences and Disorders (J.F.), University of South Carolina, Columbia; Department of Neurology (L.B.), Medical University of South Carolina, Charleston; and Department of Cognitive Science (A.E.H.), Johns Hopkins University, Baltimore, MD.
Zafer KeserFrom the Departments of Neurology (S.S., Z.K., A.W., A.E.H.) and Physical and Medicine & Rehabilitation (A.E.H.), Johns Hopkins University School of Medicine, Baltimore, MD; Departments of Psychology (C.R.) and Communication Sciences and Disorders (J.F.), University of South Carolina, Columbia; Department of Neurology (L.B.), Medical University of South Carolina, Charleston; and Department of Cognitive Science (A.E.H.), Johns Hopkins University, Baltimore, MD.ORCID 0000-0001-6415-0874
Chris RordenFrom the Departments of Neurology (S.S., Z.K., A.W., A.E.H.) and Physical and Medicine & Rehabilitation (A.E.H.), Johns Hopkins University School of Medicine, Baltimore, MD; Departments of Psychology (C.R.) and Communication Sciences and Disorders (J.F.), University of South Carolina, Columbia; Department of Neurology (L.B.), Medical University of South Carolina, Charleston; and Department of Cognitive Science (A.E.H.), Johns Hopkins University, Baltimore, MD.
Leonardo BonilhaFrom the Departments of Neurology (S.S., Z.K., A.W., A.E.H.) and Physical and Medicine & Rehabilitation (A.E.H.), Johns Hopkins University School of Medicine, Baltimore, MD; Departments of Psychology (C.R.) and Communication Sciences and Disorders (J.F.), University of South Carolina, Columbia; Department of Neurology (L.B.), Medical University of South Carolina, Charleston; and Department of Cognitive Science (A.E.H.), Johns Hopkins University, Baltimore, MD.
Julius FridrikssonFrom the Departments of Neurology (S.S., Z.K., A.W., A.E.H.) and Physical and Medicine & Rehabilitation (A.E.H.), Johns Hopkins University School of Medicine, Baltimore, MD; Departments of Psychology (C.R.) and Communication Sciences and Disorders (J.F.), University of South Carolina, Columbia; Department of Neurology (L.B.), Medical University of South Carolina, Charleston; and Department of Cognitive Science (A.E.H.), Johns Hopkins University, Baltimore, MD.
Alexandra WalkerFrom the Departments of Neurology (S.S., Z.K., A.W., A.E.H.) and Physical and Medicine & Rehabilitation (A.E.H.), Johns Hopkins University School of Medicine, Baltimore, MD; Departments of Psychology (C.R.) and Communication Sciences and Disorders (J.F.), University of South Carolina, Columbia; Department of Neurology (L.B.), Medical University of South Carolina, Charleston; and Department of Cognitive Science (A.E.H.), Johns Hopkins University, Baltimore, MD.
Argye Elizabeth HillisFrom the Departments of Neurology (S.S., Z.K., A.W., A.E.H.) and Physical and Medicine & Rehabilitation (A.E.H.), Johns Hopkins University School of Medicine, Baltimore, MD; Departments of Psychology (C.R.) and Communication Sciences and Disorders (J.F.), University of South Carolina, Columbia; Department of Neurology (L.B.), Medical University of South Carolina, Charleston; and Department of Cognitive Science (A.E.H.), Johns Hopkins University, Baltimore, MD. argye@jhmi.edu.ORCID 0000-0002-5192-1171
Johns Hopkins University · US

Funding

Telerehab for Aphasia (TERRA)P50DC014664 · NIDCD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI HICKOK, GREGORY · 2016 to 2025
$25.0M
Neural Basis of Lexical Deficits in Hyperacute StrokeR01DC005375 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI Argye E. Hillis · 2002 to 2026
$11.8M
The Neural Basis of Impaired Affective Prosody in Alzheimer's Disease and Frontotemporal DegenerationR01DC015466 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI HILLIS, ARGYE E. · 2017 to 2021
$3.5M
NIDCD NIH HHS P50 DC014664NIDCD NIH HHS R01 DC005375NIDCD NIH HHS R01 DC015466
6 · The paper itself

Abstract

BACKGROUND AND

objectivesHemispatial neglect is a heterogeneous and complex disorder that can be classified by frame of reference for "left" vs "right," including viewer-centered neglect (VCN, affecting the contralesional side of the view), stimulus-centered neglect (SCN, affecting the contralesional side of the stimulus, irrespective of its location with respect to the viewer), or both. We investigated the effect of acute stroke lesions on the connectivity of neural networks that underlie VCN or SCN.

methodsA total of 174 patients within 48 hours of acute right hemispheric infarct underwent a detailed hemispatial neglect assessment that included oral reading, scene copy, line cancellation, gap detection, horizontal line bisection tests, and MRI. Each patient's connectivity map was generated. We performed a linear association analysis between network connectivity strength and continuous measures of neglect to identify lesion-induced disconnections associated with the presence or severity of VCN and SCN. Results were corrected for multiple comparisons.

resultsAbout 42% of the participants with right hemisphere stroke had at least one type of neglect. The presence of any type of neglect was associated with lesions to tracts connecting the right inferior parietal cortex, orbitofrontal cortex, and right thalamus to other right-hemispheric structures. VCN only was strongly associated with tracts connecting the right putamen to other brain regions and tracts connecting right frontal regions with other brain regions. The presence of both types of neglect was most strongly associated with tracts connecting the right inferior and superior parietal cortex to other brain regions and those connecting left or right mesial temporal cortex to other brain regions. DISCUSSION: Our study provides new evidence for the specific white matter tracts where disruption can cause hemispatial neglect in a relatively large number of participants and homogeneous time after onset. We obtained MRI and behavioral testing acutely, before the opportunity for rehabilitation or substantial recovery. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that damage to specific white matter tracts identified on MRI are associated with the presence of neglect following right hemispheric stroke.

Indexed as

ConnectomePerceptual DisordersStrokeBrainFunctional LateralityHumansMagnetic Resonance ImagingNeuropsychological TestsParietal Lobe

Identifiers

PMID35263271
PMCPMC8762585
OpenAlexW4206250984

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.