Evidence map›Paper›PMID 35263230›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Bisphenol A replacement chemicals, BPF and BPS, induce protumorigenic changes in human mammary gland organoid morphology and proteome.

Juliane Winkler, Pengyuan Liu, Kiet Phong, Johanna H Hinrichs, Nassim Ataii, Katherine Williams, Elin Hadler-Olsen, Susan Samson, Zev J Gartner, Susan Fisher and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
6.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 59 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 3 countries.

Juliane WinklerDepartment of Anatomy, University of California, San Francisco, CA 94143.ORCID 0000-0002-9762-1721
Pengyuan LiuDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CA 94143.
Kiet PhongDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.
Johanna H HinrichsDepartment of Anatomy, University of California, San Francisco, CA 94143.
Nassim AtaiiDepartment of Anatomy, University of California, San Francisco, CA 94143.
Katherine WilliamsDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CA 94143.
Elin Hadler-OlsenDepartment of Anatomy, University of California, San Francisco, CA 94143.ORCID 0000-0001-8476-9439
Susan SamsonDepartment of Anatomy, University of California, San Francisco, CA 94143.
Zev J GartnerDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.
Susan FisherDepartment of Anatomy, University of California, San Francisco, CA 94143.ORCID 0000-0001-7745-4850
Zena WerbDepartment of Anatomy, University of California, San Francisco, CA 94143.
University of California, San Francisco · USUniversity of Massachusetts Lowell · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SignificanceBisphenol A (BPA), found in many plastic products, has weak estrogenic effects that can be harmful to human health. Thus, structurally related replacements-bisphenol S (BPS) and bisphenol F (BPF)-are coming into wider use with very few data about their biological activities. Here, we compared the effects of BPA, BPS, and BPF on human mammary organoids established from normal breast tissue. BPS disrupted organoid architecture and induced supernumerary branching. At a proteomic level, the bisphenols altered the abundance of common targets and those that were unique to each compound. The latter included proteins linked to tumor-promoting processes. These data highlighted the importance of testing the human health effects of replacements that are structurally related to chemicals of concern.

Indexed as

Benzhydryl CompoundsCarcinogenesisEstrogensMammary Glands, HumanPhenolsProteomeSulfonesBisphenol A CompoundsBisphenol F CompoundsBisphenol S CompoundsHumansOrganoidsProteomicsBenzhydryl Compoundsbisphenol ABisphenol A Compoundsbisphenol FBisphenol F Compoundsbisphenol SBisphenol S CompoundsEstrogensPhenolsProteomeSulfonesbisphenolsbreast cancerglobal proteomicsmammary glandorganoids

Identifiers

PMID35263230
PMCPMC8931256
OpenAlexW4220924628

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.