ArticleScience advances2022
Motor cortical output for skilled forelimb movement is selectively distributed across projection neuron classes.
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mapping the multi-scale landscape of vascular cognitive impairment: from structural atrophy networks to cellular and neurochemical substrates.Journal of neurology · 2026Pooled it
- A cortical output channel for perceptual categorization.Science advances · 2026Article
- Cortico-basal oscillations index naturalistic movements during deep brain stimulation.Brain : a journal of neurology · 2026Article
- Brain-Wide Activations Related to Forepaw Force Control Identified by Behaving Mouse FMRI.eNeuro · 2026Article
- Article
- Conserved role of primary motor cortex in the control of prehension in mice and macaques.Cell reports · 2026Article
- Developmental molecular signatures define de novo cortico-brainstem circuit for skilled forelimb movement.Nature communications · 2026Article
- The role of dopamine-sensitive motor cortical circuits in the development and execution of skilled forelimb movements.iScience · 2026Article
- Motor cortex somatostatin interneurons adaptively shape the structure of action sequences.Nature communications · 2026Article
- Corticothalamic communication for action coordination in a skilled motor behavior.Nature neuroscience · 2026Article
- Mouse sensorimotor cortex reflects complex kinematic details during reaching and grasping.eLife · 2026Article
- Diversity in Whisking-Related Dynamics of Layer 5 Neurons in the Motor Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Motor Cortical Output Integrates Distorted Proprioceptive Feedback.bioRxiv : the preprint server for biology · 2025Article
- Combining gamma neuromodulation and robotic rehabilitation after a stroke restores parvalbumin interneuron dynamics and improves motor recovery in mice.PLoS biology · 2025Article
- A neural manifold view of the brain.Nature neuroscience · 2025Review
- Corticothalamic neurons in motor cortex have a permissive role in motor execution.Nature communications · 2025Article
- Article
- Dissociable roles of distinct thalamic circuits in learning reaches to spatial targets.Nature communications · 2025Article
- Cerebellar control of targeted tongue movements.The Journal of physiology · 2025Article
- Supraspinal Plasticity of Axonal Projections From the Motor Cortex After Spinal Cord Injury in Macaques.The Journal of comparative neurology · 2024Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The interaction of descending neocortical outputs and subcortical premotor circuits is critical for shaping skilled movements. Two broad classes of motor cortical output projection neurons provide input to many subcortical motor areas: pyramidal tract (PT) neurons, which project throughout the neuraxis, and intratelencephalic (IT) neurons, which project within the cortex and subcortical striatum. It is unclear whether these classes are functionally in series or whether each class carries distinct components of descending motor control signals. Here, we combine large-scale neural recordings across all layers of motor cortex with cell type-specific perturbations to study cortically dependent mouse motor behaviors: kinematically variable manipulation of a joystick and a kinematically precise reach-to-grasp. We find that striatum-projecting IT neuron activity preferentially represents amplitude, whereas pons-projecting PT neurons preferentially represent the variable direction of forelimb movements. Thus, separable components of descending motor cortical commands are distributed across motor cortical projection cell classes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.