Evidence map›Paper›PMID 35262975›Full record

SynthesisClinical transplantation2022

What is the optimal anesthetic monitoring regarding immediate and short-term outcomes after liver transplantation?-A systematic review of the literature and expert panel recommendations.

Thomas M A Fernandez, Nick Schofield, Claus G Krenn, Nicole Rizkalla, Michael Spiro, Dimitri Aristotle Raptis, Andre M De Wolf, William T Merritt, ERAS4OLT.org Working Group

Open access · bronzeAbstract readSystematic Review
In one paragraph

Synthesis in Clinical transplantation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Thomas M A FernandezDepartment of Anesthesia and Perioperative Medicine, Auckland City Hospital, Auckland, New Zealand.
Nick SchofieldDepartment of Anesthesia and Intensive Care Medicine, Royal Free Hospital, London, UK.
Claus G KrennDepartment of Anesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Vienna, Austria.
Nicole RizkallaDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins Hospital, Baltimore, Maryland, USA.
Michael SpiroDepartment of Anesthesia and Intensive Care Medicine, Royal Free Hospital, London, UK.
Dimitri Aristotle RaptisClinical Service of HPB Surgery and Liver Transplantation, Royal Free Hospital, London, UK.
Andre M De WolfDepartment of Anesthesiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
William T MerrittDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins Hospital, Baltimore, Maryland, USA.
ERAS4OLT.org Working GroupDepartment of Anesthesia and Perioperative Medicine, Auckland City Hospital, Auckland, New Zealand.
University College London · GBJohns Hopkins Hospital · USMedical University of Vienna · ATNorthwestern University · USUniversity of Auckland · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLiver transplant centers vary in approach to intraoperative vascular accesses, monitoring of cardiac function and temperature management. Evidence is limited regarding impact of selected modalities on postoperative outcomes.

objectivesTo review the literature and provide expert panel recommendations on optimal intraoperative arterial blood pressure (BP), central venous pressure (CVP), and vascular accesses, monitoring of cardiac function and intraoperative temperature management regarding immediate and short-term outcomes after orthotopic liver transplant (OLT).

methodsSystematic review following PRISMA guidelines and recommendations using the GRADE approach derived from an international expert panel. Recommendations made for: (1) Vascular accesses, arterial BP and CVP monitoring, (2) cardiac function monitoring, and (3) Intraoperative temperature management (CRD42021239908).

resultsOf 2619 articles screened 16 were included. Studies were small, retrospective, and observational. Vascular access studies demonstrated low rates of insertion complications. TEE studies demonstrated low rates of esophageal hemorrhage. One study found lower hospital-LOS and 30-day mortality in patients monitored with both PAC and TEE. Other monitoring studies were heterogenous in design and outcomes. Temperature studies showed increased blood transfusion and ventilation times in hypothermic groups.

conclusionsRecommendations were made for; routine arterial and CVP monitoring as a minimum standard of practice, consideration of discrepancy between peripheral and central arterial BP in patients with hemodynamic instability and high vasopressor requirements, and routine use of high flow cannulae while monitoring for extravasation and hematoma formation. Availability and expertise in PAC and/or TEE monitoring is strongly recommended particularly in hemodynamic instability, portopulmonary HT and/or cardiac dysfunction. TEE use is recommended as an acceptable risk in patients with treated esophageal varices and is an effective diagnostic tool for emergency cardiovascular collapse. Maintenance of intraoperative normothermia is strongly recommended.

Indexed as

Liver TransplantationCentral Venous PressureHumansMonitoring, IntraoperativeRetrospective StudiesVasoconstrictor AgentsVasoconstrictor Agentscardiac output or hemodynamic monitoringcentral venous accesshyperthermiahypothermiaLiDCOliver transplantationmonitoringor FloTracPiCCOpulmonary artery catheterthermoregulationtransesophageal echocardiographyvenous or arterial access

Identifiers

PMID35262975
PMCPMC10077907
OpenAlexW4220745878

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.