Evidence map›Paper›PMID 35262860›Full record

Observational studyJournal of endocrinological investigation2022

Testosterone-to-estradiol ratio and platelet thromboxane release in ischemic heart disease: the EVA project.

V Raparelli, C Nocella, M Proietti, G F Romiti, B Corica, S Bartimoccia, L Stefanini, A Lenzi, N Viceconte, G Tanzilli and 6 more

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of endocrinological investigation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Sex differences at the platelet-vascular interface.Internal and emergency medicine · 2022
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

V RaparelliDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy. valeria.raparelli@unife.it.ORCID http://orcid.org/0000-0002-2100-5682
C NocellaDepartment of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
M ProiettiGeriatric Unit, IRCCS Istituti Clinici Scientifici Maugeri, Milan, Italy.
G F RomitiDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
B CoricaDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
S BartimocciaDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
L StefaniniDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
A LenziDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
N ViceconteDepartment of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
G TanzilliDepartment of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
V CammisottoDepartment of General Surgery and Surgical Speciality Paride Stefanini, Sapienza University of Rome, Rome, Italy.
L PiloteCentre for Outcomes Research and Evaluation, McGill University Health Centre Research Institute, Montreal, QC, Canada.
R CangemiDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
S BasiliDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
R CarnevaleDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
EVA Collaborators
Sapienza University of Rome · ITClinica Mediterranea · ITMcGill University Health Centre · CAUniversity of Alberta · CAUniversity of Liverpool · GB

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca Scientific Independence of Young Investigator (SIR) - RBSI14HNVT
6 · The paper itself

Abstract

backgroundData on the interplay between sexual hormones balance, platelet function and clinical outcomes of adults with ischemic heart disease (IHD) are still lacking.

objectiveTo assess the association between the Testosterone (T)-to-Estradiol (E2) Ratio (T/E2) and platelet activation biomarkers in IHD and its predictive value on adverse outcomes.

methodsThe EVA study is a prospective observational study of consecutive hospitalized adults with IHD undergoing coronary angiography and/or percutaneous coronary interventions. Serum T/E2 ratios E2, levels of thromboxane B

resultsAmong 509 adults with IHD (mean age 67 ± 11 years, 30% females), males were older with a more adverse cluster of cardiovascular risk factors than females. Acute coronary syndrome and non-obstructive coronary artery disease were more prevalent in females versus males. The lower sex-specific T/E2 ratios identified adults with the highest level of serum TxB

conclusionAmong adults with IHD, higher T/E2 ratio was associated with a lower long-term risk of fatal events. The effect of sex hormones on the platelet thromboxane release may partially explain such finding.

Indexed as

Blood PlateletsMyocardial IschemiaAdultAgedEstradiolFemaleHumansMaleMiddle AgedTestosteroneThromboxanesEstradiolTestosteroneThromboxanesEstradiolIschemic heart diseaseMortalityTestosteroneThromboxane

Identifiers

PMID35262860
PMCPMC9184432
OpenAlexW4220786776

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.