Evidence map›Paper›PMID 35262788›Full record

Observational studyWiener klinische Wochenschrift2022

Usefulness of the trabecular bone score in maintenance dialysis patients : A single center observational study.

Oliver Malle, Markus Bergthaler, Peter Krisper, Karin Amrein, Hans Peter Dimai, Alexander H Kirsch, Alexander R Rosenkranz, Thomas Pieber, Barbara Obermayer-Pietsch, Astrid Fahrleitner-Pammer

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Wiener klinische Wochenschrift, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Oliver MalleDepartment of Internal Medicine, Div. of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria. oliver.malle@medunigraz.at.
Markus BergthalerDepartment of Internal Medicine, Div. of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria.
Peter KrisperDepartment of Internal Medicine, Div. of Nephrology, Medical University of Graz, Graz, Austria.
Karin AmreinDepartment of Internal Medicine, Div. of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria.
Hans Peter DimaiDepartment of Internal Medicine, Div. of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria.
Alexander H KirschDepartment of Internal Medicine, Div. of Nephrology, Medical University of Graz, Graz, Austria.
Alexander R RosenkranzDepartment of Internal Medicine, Div. of Nephrology, Medical University of Graz, Graz, Austria.
Thomas PieberDepartment of Internal Medicine, Div. of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria.
Barbara Obermayer-PietschDepartment of Internal Medicine, Div. of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria.
Astrid Fahrleitner-PammerDepartment of Internal Medicine, Div. of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria.
Medical University of Graz · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe number of dialysis patients is steadily increasing. Associated comorbidities include impaired bone and mineral metabolism, termed chronic kidney disease-mineral and bone disorder (CKD-MBD), leading to a high fracture risk, increased morbidity and mortality and impaired quality of life. While the bone density is assessed with dual-energy X‑ray absorptiometry (DXA), the trabecular bone score (TBS) captures the image texture as a potential index of skeletal microarchitecture. The aim of this study was to evaluate the clinical relevance of DXA and TBS in dialysis patients with and without prevalent fractures.

methodsBone disorders were evaluated in 82 dialysis patients (37% female) at the University Hospital of Graz, Austria, by DXA including the assessment of the TBS based on a patient interview and the local routine patient database software. The patient cohort was stratified by having sustained a fragility fracture in the past or not. Descriptive statistics, t‑tests for continuous variables and χ

resultsOf the 82 patients, 32 (39%) had a positive history of fractures. There was a significant association between dialysis duration and fracture prevalence (p < 0.05) as well as musculoskeletal pain (p < 0.01). No significant correlation between DXA/TBS parameters and musculoskeletal pain could be established. The DXA scores did not correlate with fracture prevalence with the exception of DXA radius measurements; however, fracture prevalence significantly correlated inversely with TBS (p < 0.001).

conclusionThe use of DXA has a limited role in fracture prediction in dialysis patients; however, the TBS seems to add information as an additional tool for fracture risk estimation in this patient population.

Indexed as

Musculoskeletal PainOsteoporotic FracturesAbsorptiometry, PhotonBone DensityCancellous BoneFemaleHumansLumbar VertebraeMaleQuality of LifeRenal DialysisBone imagingBone microarchitectureChronic kidney diseaseMineral and bone disorderOsteoporosis

Identifiers

PMID35262788
PMCPMC9213369
OpenAlexW4220667852

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.