Observational studyJournal of neurology2022
Undetected ophthalmological disorders in Parkinson's disease.
Observational study in Journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Prevalence and characteristics of dry eye disease in Parkinson's disease: a systematic review and meta-analysis.Scientific reports · 2022Pooled it
- Association Between Substantia Nigra Hyperechogenicity and Central Macular Thickness in Parkinson's Disease.Biomedicines · 2026Article
- Comparative study of refractive errors between patients with Parkinson's disease versus age- and sex-matched healthy controls.BMC neurology · 2026Article
- Article
- Comparison of binocular vision indices in Parkinson's disease patientsInternational journal of ophthalmology · 2026Article
- Exploring medication experiences, behaviours, and reminder technology preferences in people with Parkinson's disease: a survey.Frontiers in digital health · 2026Article
- Ocular Surface Changes Associated with Neurological Diseases.Medicina (Kaunas, Lithuania) · 2025Review
- Optic Disc Pallor in Parkinson's Disease: A UK Biobank Study.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Evaluation of different fall risk screening tools for risk prediction of ophthalmology inpatients.BMC ophthalmology · 2025Article
- Evaluation of Accommodation Amplitude and Convergence Insufficiency in Patients with Multiple Sclerosis.Neuro-ophthalmology (Aeolus Press) · 2025Article
- Retinal Alterations Predict Early Prodromal Signs of Neurodegenerative Disease.International journal of molecular sciences · 2024Review
- Gait Adaptability and the Effect of Ocular Disorders on Visually Guided Walking in Parkinson's Disease.Journal of Parkinson's disease · 2024Article
- Quotidian Profile of Vergence Angle in Ambulatory Subjects Monitored With Wearable Eye Tracking Glasses.Translational vision science & technology · 2023Article
- Dry eye in Parkinson's disease: a narrative review.Frontiers in neurology · 2023Review
- Glial metabolic alterations during glaucoma pathogenesis.Frontiers in ophthalmology · 2023Review
- Editorial: Multimorbidity in the context of neurodegenerative disorders.Frontiers in neuroscience · 2022Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundOphthalmological disorders are common and frequently disabling for people with Parkinson's disease (PD). However, details on the prevalence, severity and impact of ophthalmological disorders thus far lacking. We aimed to identify PD patients with undetected ophthalmological disorders in a large cross-sectional, observational study.
methodsWe previously delivered a screening questionnaire to detect ophthalmological symptoms (Visual impairment in PD questionnaire; VIPD-Q) to 848 patients. Here, we report on a subgroup of 102 patients who received complete ophthalmological assessment aimed at identifying clinically relevant ophthalmological diseases, which were classified as either vison-threatening or not. Impact on daily life functioning was measured using the visual functioning-25 questionnaire (VFQ-25) and fall frequency.
resultsAlmost all patients (92%) had one or more clinically relevant ophthalmological disorders. Of those, 77% had a potentially vision-threatening disease, while 34% had a potentially treatable ophthalmological disease which impacted on quality of life. The most prevalent ophthalmological disorders were dry eyes (86%), ocular misalignment (50%) and convergence insufficiency (41%). We found a weak but significant association between clinically relevant ophthalmological diseases and both fall frequency (R
conclusionsSurprisingly, in our study sample, many participants manifested previously undetected ophthalmological diseases, most of which threatened vision, impacted on daily life functioning and were amenable to treatment. Screening for these ophthalmological disorders using a questionnaire asking about symptoms seems insufficient. Instead, episodic ophthalmological assessments should be considered for PD patients, aiming to identify vision-threatening yet treatable diseases.
trial registrationDutch Trial Registration, NL7421.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.