Evidence map›Paper›PMID 35262756›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2022

Very early infective endocarditis after transcatheter aortic valve replacement.

Vassili Panagides, Mohamed Abdel-Wahab, Norman Mangner, Eric Durand, Nikolaj Ihlemann, Marina Urena, Costanza Pellegrini, Francesco Giannini, Piotr Scislo, Zenon Huczek and 25 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Observational
  5. Review
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  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors at 20 institutions in 8 countries.

Vassili PanagidesQuebec Heart and Lung Institute, Laval University, Quebec City, Canada.
Mohamed Abdel-WahabHeart Center, Leipzig University, Leipzig, Germany.
Norman MangnerHeart Center, Leipzig University, Leipzig, Germany.
Eric DurandDepartment of Cardiology, Normandie Univ, UNIROUEN, U1096, CHU Rouen, 76000, Rouen, France.
Nikolaj IhlemannRighospitalet, Copenhagen, Denmark.
Marina UrenaBichat Hôpital, Paris, France.
Costanza PellegriniDeutsches Herzzentrum München, Munich, Germany.
Francesco GianniniMaria Cecilia Hospital, GVM Care and Research, Cotignola, RA, Italy.
Piotr ScisloDepartment of Cardiology, Medical University of Warsaw, Warsaw, Poland.
Zenon HuczekDepartment of Cardiology, Medical University of Warsaw, Warsaw, Poland.
Martin LandtHeart Center, Segeberger Kliniken, Bad Segeberg, Germany.
Vincent AuffretUniv Rennes, CHU Rennes, Inserm, LTSI - UMR1099, 35000, Rennes, France.
Jan Malte SinningHeart Center Bonn, Bonn, Germany.
Asim N CheemaSt Michaels Hospital, Toronto, Canada.
Luis Nombela-FrancoCardiovascular Institute, Hospital Clínico San Carlos, IdISSC, Madrid, Spain.
Chekrallah ChamandiHôpital Européen Georges-Pompidou, Paris, France.
Francisco Campelo-ParadaHôpital Rangueil, Toulouse, France.
Erika Munoz-GarciaHospital Universitario Virgen de la Victoria, Malaga, Spain.
Howard C HerrmannHospital of the University of Pennsilvania, Philadelphia, USA.
Luca TestaIRCCS Pol, San Donato, Milan, Italy.
Won-Keun KimKerckhoff Heart and Thorax Centre, Bad Nauheim, Germany.
Helene EltchaninoffDepartment of Cardiology, Normandie Univ, UNIROUEN, U1096, CHU Rouen, 76000, Rouen, France.
Lars SøndergaardRighospitalet, Copenhagen, Denmark.
Dominique HimbertBichat Hôpital, Paris, France.
Oliver HusserDeutsches Herzzentrum München, Munich, Germany.
Azeem LatibMaria Cecilia Hospital, GVM Care and Research, Cotignola, RA, Italy.
Hervé Le BretonUniv Rennes, CHU Rennes, Inserm, LTSI - UMR1099, 35000, Rennes, France.
Clement ServozHôpital Rangueil, Toulouse, France.
Philippe GervaisQuebec Heart and Lung Institute, Laval University, Quebec City, Canada.
David Del ValQuebec Heart and Lung Institute, Laval University, Quebec City, Canada.
Axel LinkeHeart Center, Leipzig University, Leipzig, Germany.
Lisa CrusiusHeart Center, Leipzig University, Leipzig, Germany.
Holger ThieleHeart Center, Leipzig University, Leipzig, Germany.
David HolzheyHeart Center, Leipzig University, Leipzig, Germany.
Josep Rodés-CabauQuebec Heart and Lung Institute, Laval University, Quebec City, Canada. josep.rodes@criucpq.ulaval.ca.ORCID http://orcid.org/0000-0001-8237-7095
Leipzig Heart Institute · DEUniversité Laval · CADeutsches Herzzentrum München · DEEndothélium, valvulopathies et insuffisance cardiaque · FRHôpital Bichat-Claude-Bernard · FRHôpital Rangueil · FRInserm · FRMedical University of Warsaw · PLRigshospitalet · DKHôpital Européen Georges-Pompidou · FRHospital Clínico San Carlos · ESHospital Clínico Universitario Virgen de la Victoria · ESHospital of the University of Pennsylvania · USIRCCS Policlinico San Donato · ITKerckhoff Klinik · DELung Institute · USMaria Cecilia Hospital · ITMontefiore Medical Center · USSegeberger Kliniken · DESt. Michael's Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundScarce data exist about early infective endocarditis (IE) after trans-catheter aortic valve replacement (TAVR).

objectiveThe objective was to evaluate the characteristics, management, and outcomes of very early (VE) IE (≤ 30 days) after TAVR.

methodsThis multicenter study included a total of 579 patients from the Infectious Endocarditis after TAVR International Registry who had the diagnosis of definite IE following TAVR.

resultsNinety-one patients (15.7%) had VE-IE. Factors associated with VE-IE (vs. delayed IE (D-IE)) were female gender (p = 0.047), the use of self-expanding valves (p < 0.001), stroke (p = 0.019), and sepsis (p < 0.001) after TAVR. Staphylococcus aureus was the main pathogen among VE-IE patients (35.2% vs. 22.7% in the D-IE group, p = 0.012), and 31.2% of Staphylococcus aureus infections in the VE-IE group were methicillin-resistant (vs. 14.3% in the D-IE group, p = 0.001). The second-most common germ was enterococci (34.1% vs. 24.4% in D-IE cases, p = 0.05). VE-IE was associated with very high in-hospital (44%) and 1-year (54%) mortality rates. Acute renal failure following TAVR (p = 0.001) and the presence of a non-enterococci pathogen (p < 0.001) were associated with an increased risk of death.

conclusionA significant proportion of IE episodes following TAVR occurs within a few weeks following the procedure and are associated with dismal outcomes. Some baseline and TAVR procedural factors were associated with VE-IE, and Staphylococcus aureus and enterococci were the main causative pathogens. These results may help to select the more appropriate antibiotic prophylaxis in TAVR procedures and guide the initial antibiotic therapy in those cases with a clinical suspicion of IE. Very early infective endocarditis after trans-catheter aortic valve replacement. VE-IE indicates very early infective endocarditis (≤30 days post TAVR). D-IE indicates delayed infective endocarditis.

Indexed as

Aortic Valve StenosisEndocarditisEndocarditis, BacterialHeart Valve ProsthesisStaphylococcal InfectionsTranscatheter Aortic Valve ReplacementAnti-Bacterial AgentsAortic ValveFemaleHumansMaleRisk FactorsAnti-Bacterial AgentsAnti-bio-prophylaxisHealthcare-associated infectionHeart surgeryInfective endocarditisTAVR

Identifiers

PMID35262756
OpenAlexW4220920212

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.