ArticleArquivos brasileiros de cardiologia2022
Association between the Severity of Coronary Artery Disease and Lung Cancer: A Pilot Cross-Sectional Study.
Article in Arquivos brasileiros de cardiologia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 8 citations in OpenAlex.
- Clinical Research Progress in the Treatment and Prognosis of Comorbid Coronary Heart Disease and Lung Cancer.Reviews in cardiovascular medicine · 2026Review
- Coronary artery calcification burden in cancer vs. non-cancer populations: a systematic review and meta-analysis.Cardio-oncology (London, England) · 2026Article
- Postdischarge cancer and mortality in patients with coronary artery disease: a retrospective cohort study.Journal of geriatric cardiology : JGC · 2025Article
- Exposure to major coronary heart disease events reduces lung cancer risk: a mendelian randomization study based on a European population.BMC cancer · 2025Article
- High-fat-diet-induced obesity promotes simultaneous progression of lung cancer and atherosclerosis in apolipoprotein E-knockout mice.Cancer innovation · 2024Article
- Review
- Impact of continuous care on cardiac function in patients with lung cancer complicated by coronary heart disease.World journal of clinical cases · 2024Article
- Inflammation-based different association between anatomical severity of coronary artery disease and lung cancer.Journal of geriatric cardiology : JGC · 2022Article
- Neoplasms and the Evaluation of Risk of Cardiovascular Disease.Arquivos brasileiros de cardiologia · 2022Article
- Are cardiovascular comorbidities always associated with a worse prognosis in patients with lung cancer?Frontiers in cardiovascular medicine · 2022Review
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7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe direct relationship between coronary artery disease (CAD) and lung cancer is not well known.
objectiveTo investigate the association between the anatomical severity of CAD and lung cancer.
methodsThree-hundred study patients, including 75 recently diagnosed lung cancer patients and 225 matched non-cancer patients, underwent coronary angiography during hospitalization without previous percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). The SYNTAX score (SXscore) was used to assess the severity of CAD. A high SXscore (SXhigh) grade was defined as SXscore > 15 (the highest quartile of the SXscore). The Cochran-Armitage test for trend was used to assess the distribution of patients' SXscores. Logistic regression analysis was used to assess the association between the severity of CAD and lung cancer. P-values were set when significance level was 5%.
resultsThe distribution trend of patients' SXscore by quartiles was different between lung cancer patients and control patients (from the lowest to the highest quartile: 20.0%, 20.0%, 24.0%, 36.0% vs. 26.7%, 26.2%, 25.8%, 21.3%, p=0.022). The SX high rate was higher in lung cancer patients than in control patients (36.0% vs. 21.3%, p=0.011).The highest quartile of the SXscore showed higher risk of lung cancer in comparison to the lowest quartile (OR: 2,250, 95%CI: 1,077 to 4,699 ; P-trend= 0.016). After adjustment, patients in the highest quartile of the SXscore had higher risk of lung cancer (OR: 2,149, 95%CI: 1,008 to 4,584; P-trend= 0.028). Patients with high SXscore (> 15) had 1,985 times more chances of having lung cancer (95%CI: 1,105-3,563, P= 0.022).
conclusionsThe anatomical severity of CAD is associated with the risk of lung cancer, which indicates that a thorough lung cancer screening may be significant among severe CAD patients.
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