ArticleTissue engineering. Part C, Methods2022
A Mini-Pig Mandibular Defect Model for Evaluation of Craniomaxillofacial Bone Regeneration.
Article in Tissue engineering. Part C, Methods, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Preclinical evaluation of patient-specific 3D-printed PDLLA/SrHAp implants in a minipig segmental mandibular defect model.Materials today. Bio · 2026Article
- An Experimental Study on 3D-Printed Gyroid-Shaped TC4 Porous Scaffolds Guiding Angiogenesis and Osteogenesis in Bone Defect Areas.ACS biomaterials science & engineering · 2026Article
- Dental Implant Osseointegration Following Mandibular Augmentation Using 3D Printed Hydroxyapatite Blocks. An Experimental In Vivo Study.Clinical oral implants research · 2026Article
- Bone Regeneration in SLS-Manufactured Resorbable 3D-Scaffolds-An Experimental Pilot Study in Minipigs.Polymers · 2025Article
- Advancing Scaffold Architecture for Bone Tissue Engineering: A Comparative Study of 3D-Printed β-TCP Constructs in Dynamic Culture with pBMSC.Journal of functional biomaterials · 2025Article
- Exploring the correlation between dental procedures and trigemino-cardiac reflex.Journal of dental sciences · 2025Article
- A novel Liesegang-patterned mineralized hydrogel drives bone regeneration with microstructure control.Materials today. Bio · 2025Article
- The tooth transformer® revolution: autologous dentin biomaterials and platelet concentrates in oral regeneration. A parallel narrative systematic review.Frontiers in dental medicine · 2025Review
- Magnesium Nanocomposite Hydrogel Reverses the Pathologies to Enhance Mandible Regeneration.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Poly(dl-lactide) Polymer Blended with Mineral Phases for Extrusion 3D Printing-Studies on Degradation and Biocompatibility.Polymers · 2024Article
- Lateral Bone Augmentation Using a Three-Dimensional-Printed Polymeric Chamber to Compare Biomaterials.Tissue engineering. Part C, Methods · 2023Article
- Determination of critical-sized defect of mandible in a rabbit model: Micro-computed tomography, and histological evaluation.Heliyon · 2023Article
- Regenerative Potential of Hydroxyapatite-Based Ceramic Biomaterial on Mandibular Cortical Bone: AnBiomedicines · 2023Article
- Fast Degradable Calcium Phosphate Cement for Maxillofacial Bone Regeneration.Tissue engineering. Part A · 2023Article
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Craniomaxillofacial bone defects represent a clinical challenge in the fields of maxillofacial surgery and (implant) dentistry. Regeneration of these bone defects requires the application of bone graft materials that facilitate new bone formation in a safe, reliable, and predictive manner. In addition to autologous bone graft, several types of (synthetic) bone substitute materials have become clinically available, and still major efforts are focused on improving such bone substitute materials by optimizing their properties. Given the regulatory necessity to evaluate the performance of new bone substitute materials for craniomaxillofacial bone regeneration in a large animal model with similarity to human bone before clinical application, we here describe a mini-pig mandibular bone defect model that allows for the creation of multiple (critical-size) bone defects within the mandibular body of a single animal. As examples of bone substitute materials, we utilize both the clinically used BioOss granules and an experimental calcium phosphate cement for filling the created defects. Regarding the latter, its advantages are the injectable application within the defect site, in which the material rapidly sets, and the tailorable degradation properties via the inclusion of hydrolytically degrading polymeric particles. For both bone substitute materials, we show the suitability of the bone defect model to assess bone regeneration via histology and micro-computed tomography. Impact statement Given the regulatory necessity to evaluate the performance of new bone substitute materials for craniomaxillofacial bone regeneration in a large animal model with similarity to the human bone before clinical application, we here describe a mini-pig mandibular bone defect model that allows for the creation of multiple (critical-size) bone defects within the mandibular body of a single animal that can be used for the evaluation of the bone regenerative capacity of new bone grafting materials as well as tissue-engineered products for alveolar bone regeneration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.