Evidence map›Paper›PMID 35262374›Full record

ArticleAntimicrobial agents and chemotherapy2022

Triazolopyrimidines Target Aerobic Respiration in Mycobacterium tuberculosis.

Catherine Shelton, Matthew McNeil, Renee Allen, Lindsay Flint, Dara Russell, Bryan Berube, Aaron Korkegian, Yulia Ovechkina, Tanya Parish

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. New Triazolopyrimidines with Improved Activity againstACS medicinal chemistry letters · 2025
    Article
  4. Deep learning-driven bacterial cytological profiling to determine antimicrobial mechanisms inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. An arylsulfonamide that targets cell wall biosynthesis inAntimicrobial agents and chemotherapy · 2024
    Article
  6. Article
  7. Response ofInternational journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Catherine SheltonTB Discovery Research, Infectious Disease Research Institutegrid.53959.33, Seattle, Washington, USA.
Matthew McNeilTB Discovery Research, Infectious Disease Research Institutegrid.53959.33, Seattle, Washington, USA.
Renee AllenCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
Lindsay FlintTB Discovery Research, Infectious Disease Research Institutegrid.53959.33, Seattle, Washington, USA.
Dara RussellTB Discovery Research, Infectious Disease Research Institutegrid.53959.33, Seattle, Washington, USA.
Bryan BerubeTB Discovery Research, Infectious Disease Research Institutegrid.53959.33, Seattle, Washington, USA.
Aaron KorkegianTB Discovery Research, Infectious Disease Research Institutegrid.53959.33, Seattle, Washington, USA.
Yulia OvechkinaTB Discovery Research, Infectious Disease Research Institutegrid.53959.33, Seattle, Washington, USA.
Tanya ParishTB Discovery Research, Infectious Disease Research Institutegrid.53959.33, Seattle, Washington, USA.ORCID 0000-0001-7507-0423
Infectious Disease Research Institute · US

Funding

Gates Foundation INV-005585
6 · The paper itself

Abstract

We previously identified a series of triazolopyrimidines with antitubercular activity. We determined that Mycobacterium tuberculosis strains with mutations in QcrB, a subunit of the cytochrome

Indexed as

Mycobacterium tuberculosisAntitubercular AgentsCytochromesElectron Transport Complex IVHumansRespirationAntitubercular AgentsCytochromesElectron Transport Complex IVaerobic respirationantibiotic resistanceantibiotic tolerancetuberculosis

Identifiers

PMID35262374
PMCPMC9017309
OpenAlexW4221090512

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.