Evidence map›Paper›PMID 35262289›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2023

Prevalence of dementia and mild cognitive impairment in indigenous Bolivian forager-horticulturalists.

Margaret Gatz, Wendy J Mack, Helena C Chui, E Meng Law, Giuseppe Barisano, M Linda Sutherland, James D Sutherland, Daniel Eid Rodriguez, Raul Quispe Gutierrez, Juan Copajira Adrian and 21 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 3 pooled it
6.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Risk, protective, and biomarkers of dementia in Indigenous peoples: A systematic review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Pooled it
  3. Pooled it
  4. Article
  5. Incidence of dementia and mild cognitive impairment in two Indigenous Bolivian cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  6. Article
  7. Article
  8. The landscape of dementia research, diagnosis, treatment, and care in Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  9. Review
  10. Review
  11. Article
  12. Advancing brain health equity with Indigenous peoples: A critical imperative.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  13. Review
  14. Article
  15. Oxytocin varies across the life course in a sex-specific way in a human subsistence population.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 17 institutions in 6 countries.

Margaret GatzCenter for Economic and Social Research, University of Southern California, Los Angeles, California, USA.
Wendy J MackDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Helena C ChuiDepartment of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
E Meng LawDepartment of Neuroscience, Monash University, Melbourne, Victoria, Australia.
Giuseppe BarisanoNeuroscience Graduate Program, University of Southern California, Los Angeles, California, USA.
M Linda SutherlandMemorialCare Health Systems, Fountain Valley, California, USA.
James D SutherlandMemorialCare Health Systems, Fountain Valley, California, USA.
Daniel Eid RodriguezInstitute of Biomedical Research, Faculty of Medicine, San Simon University, Cochabamba, Bolivia.
Raul Quispe GutierrezTsimane Health and Life History Project, San Borja, Beni, Bolivia.
Juan Copajira AdrianTsimane Health and Life History Project, San Borja, Beni, Bolivia.
Jesus Bani CuataTsimane Health and Life History Project, San Borja, Beni, Bolivia.
Amy R BorensteinDivision of Epidemiology, Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego School of Medicine, La Jolla, California, USA.
Ellen E WaltersCenter for Economic and Social Research, University of Southern California, Los Angeles, California, USA.
Andrei IrimiaLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
Christopher J RowanRenown Institute for Heart and Vascular Health, Reno, Nevada, USA.
L Samuel WannDivision of Cardiology, University of New Mexico, Albuquerque, New Mexico, USA.
Adel H AllamDepartment of Cardiology, School of Medicine, Al-Azhar University, Cairo, Egypt.
Randall C ThompsonSaint Luke's Mid America Heart Institute, University of Missouri-Kansas City, Kansas City, Missouri, USA.
Michael I MiyamotoProvidence Health, Mission Viejo, California, USA.
David E MichalikMemorial Care Miller Women's and Children's Hospital, Long Beach, California, USA.
Daniel K CummingsEconomic Science Institute, Argyos School of Business and Economics, Chapman University, Orange, California, USA.
Edmond SeabrightDepartment of Anthropology, University of New Mexico, Albuquerque, New Mexico, USA.
Angela R GarciaSchool of Human Evolution and Social Change, and Center for Evolution and Medicine, Arizona State University, Tempe, Arizona, USA.
Paul L HooperDepartment of Anthropology, University of New Mexico, Albuquerque, New Mexico, USA.
Thomas S KraftDepartment of Anthropology, University of California Santa Barbara, Santa Barbara, California, USA.
Caleb E FinchLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
Gregory S ThomasMemorialCare Heart & Vascular Institute, Fountain Valley, California, USA.
Jonathan StieglitzInstitute for Advanced Study in Toulouse, Toulouse, France.
Benjamin C TrumbleSchool of Human Evolution and Social Change, and Center for Evolution and Medicine, Arizona State University, Tempe, Arizona, USA.
Michael D GurvenDepartment of Anthropology, University of California Santa Barbara, Santa Barbara, California, USA.
Hillard KaplanEconomic Science Institute, Argyos School of Business and Economics, Chapman University, Orange, California, USA.
University of Southern California · USBorneo Orangutan Survival Foundation · IDUniversity of New Mexico · USArizona State University · USChapman University · USMemorialCare Health System · USUniversity of California, Santa Barbara · USAl-Azhar University · EGHuman Longevity (United States) · USInstitute for Advanced Study in Toulouse · FRMiller Children's & Women's Hospital · USMission Heritage Medical Group · USMonash University · AURenown Regional Medical Center · USUniversity of California, Irvine · USUniversity of Missouri–Kansas City · USUniversity of San Simón · BO

Funding

USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI, ARTHUR W TOGA · 2020 to 2026
$27.8M
Testing Hypothesized Pathways Linking Infection, Physical Activity, Apoe Genotype, And Biological Sex To Low Dementia Prevalence And Reduced Brain Atrophy In Two Native American PopulationsR01AG054442 · NIA · CHAPMAN UNIVERSITY · PI CALEB E FINCH, Margaret Gatz · 2022 to 2026
$15.2M
Urban Air Pollution and Pathological Brain Aging: A Nationwide Twin Study in MenP01AG055367 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, JIU-CHIUAN, FINCH, CALEB E · 2018 to 2022
$11.5M
Brain atrophy, cognitive impairment and Alzheimer's in low CVD-risk populationRF1AG054442 · NIA · UNIVERSITY OF NEW MEXICO · PI FINCH, CALEB E, GURVEN, MICHAEL DOUGLAS · 2017 to 2020
$8.8M
NIA NIH HHS P01 AG055367NIA NIH HHS P30 AG066530NIA NIH HHS R01 AG054442NIA NIH HHS RF1 AG054442
6 · The paper itself

Abstract

introductionWe evaluated the prevalence of dementia and mild cognitive impairment (MCI) in indigenous Tsimane and Moseten, who lead a subsistence lifestyle.

methodsParticipants from population-based samples ≥ 60 years of age (n = 623) were assessed using adapted versions of the Modified Mini-Mental State Examination, informant interview, longitudinal cognitive testing and brain computed tomography (CT) scans.

resultsTsimane exhibited five cases of dementia (among n = 435; crude prevalence = 1.2%, 95% confidence interval [CI]: 0.4, 2.7); Moseten exhibited one case (among n = 169; crude prevalence = 0.6%, 95% CI: 0.0, 3.2), all age ≥ 80 years. Age-standardized MCI prevalence was 7.7% (95% CI: 5.2, 10.3) in Tsimane and 9.8% (95% CI: 4.9, 14.6) in Moseten. Cognitive impairment was associated with visuospatial impairments, parkinsonian symptoms, and vascular calcification in the basal ganglia. DISCUSSION: The prevalence of dementia in this cohort is among the lowest in the world. Widespread intracranial medial arterial calcifications suggest a previously unrecognized, non-Alzheimer's disease (AD) dementia phenotype.

Indexed as

Alzheimer DiseaseCognitive DysfunctionDementiaBoliviaDisease ProgressionHumansNeuroimagingPrevalencecognitive dysfunctiondementiamental status and dementia testsMosetenTsimane

Identifiers

PMID35262289
PMCPMC9458772
OpenAlexW4221067531

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.