ArticleDevelopment (Cambridge, England)2022
The topography of corticopontine projections is controlled by postmitotic expression of the area-mapping gene Nr2f1.
Article in Development (Cambridge, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Proline-Rich Transmembrane Protein 2 Is Variably Expressed Across Excitatory and Inhibitory Neurons in Mouse Motor Circuits.The Journal of comparative neurology · 2026Article
- Organization and development of bilateral somatosensory feedback projections in mice.iScience · 2025Article
- Software and pipelines for registration and analyses of rodent brain image data in reference atlas space.Frontiers in neuroinformatics · 2025Article
- Spatially integrated cortico-subcortical tracing data for analyses of rodent brain topographical organization.Scientific data · 2024Article
- Waxholm Space atlas of the rat brain: a 3D atlas supporting data analysis and integration.Nature methods · 2023Article
- The efferent connections of the orbitofrontal, posterior parietal, and insular cortex of the rat brain.Scientific data · 2023Article
- Article
- A neuroscientist's guide to using murine brain atlases for efficient analysis and transparent reporting.Frontiers in neuroinformatics · 2023Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Axonal projections from layer V neurons of distinct neocortical areas are topographically organized into discrete clusters within the pontine nuclei during the establishment of voluntary movements. However, the molecular determinants controlling corticopontine connectivity are insufficiently understood. Here, we show that an intrinsic cortical genetic program driven by Nr2f1 graded expression is directly implicated in the organization of corticopontine topographic mapping. Transgenic mice lacking cortical expression of Nr2f1 and exhibiting areal organization defects were used as model systems to investigate the arrangement of corticopontine projections. By combining three-dimensional digital brain atlas tools, Cre-dependent mouse lines and axonal tracing, we show that Nr2f1 expression in postmitotic neurons spatially and temporally controls somatosensory topographic projections, whereas expression in progenitor cells influences the ratio between corticopontine and corticospinal fibres passing the pontine nuclei. We conclude that cortical gradients of area-patterning genes are directly implicated in the establishment of a topographic somatotopic mapping from the cortex onto pontine nuclei.
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