Evidence map›Paper›PMID 35262071›Full record

ArticleResearch square2022

BCG revaccination qualitatively and quantitatively enhances SARS-CoV-2 spike-specific neutralizing antibody and T cell responses induced by the COVISHIELD

Srabanti Rakshit, Vasista Adiga, Asma Ahmed, Chaitra Parthiban, Nirutha Chetan Kumar, Pratibha Dwarkanath, Sudarshan Shivalingaiah, Srishti Rao, George D'Souza, Mary Dias and 9 more

Abstract readPreprint
In one paragraph

Article in Research square, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Srabanti RakshitCentre for Infectious Disease Research, Indian Institute of Science, Bangalore, India.
Vasista AdigaCentre for Infectious Disease Research, Indian Institute of Science, Bangalore, India.
Asma AhmedCentre for Infectious Disease Research, Indian Institute of Science, Bangalore, India.
Chaitra ParthibanCentre for Infectious Disease Research, Indian Institute of Science, Bangalore, India.
Nirutha Chetan KumarCentre for Infectious Disease Research, Indian Institute of Science, Bangalore, India.
Pratibha DwarkanathDivision of Nutrition, St. John's Research Institute, Bangalore, India.
Sudarshan ShivalingaiahInfectious Disease Unit, St. John's Research Institute, Bangalore, India.
Srishti RaoInfectious Disease Unit, St. John's Research Institute, Bangalore, India.
George D'SouzaDepartment of Pulmonary Medicine, St. John's Medical College, Bangalore, India.
Mary DiasInfectious Disease Unit, St. John's Research Institute, Bangalore, India.
Thomas J A MaguireDepartment of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London.ORCID 0000-0003-1034-4926
Katie DooresDepartment of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London.ORCID 0000-0002-5507-1725
Prokar DasguptaPeter Gorer Department of Immunobiology, Liver Renal Urology Transplant Gastro/Gastrointestinal Surgery, Inflammation Biology, King's College, London.
Sudhir BabjiThe Wellcome Trust Research Laboratory, Christian Medical College, Vellore, India.ORCID 0000-0002-1288-374X
Tom H M OttenhoffDept. Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0003-3706-3403
Kenneth D StuartSeattle Children's Research Institute, Seattle, Washington USA.
Stephen De RosaVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Centre, Seattle, Washington, USA.
M Juliana McElrathVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Centre, Seattle, Washington, USA.
Annapurna VyakarnamCentre for Infectious Disease Research, Indian Institute of Science, Bangalore, India.

Funding

LC: HIV Vaccine Trials NetworkUM1AI068618 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Margaret Juliana McElrath · 2011 to 2026
$483.6M
NIAID NIH HHS UM1 AI068618
6 · The paper itself

Abstract

This study tested if prior BCG revaccination can further boost immune responses subsequently induced by a widely distributed and otherwise efficacious Oxford/AstraZeneca ChAdOx1nCoV-19 vaccine, referred to as COVISHIELD

Indexed as

antibody bindingBCGCD4CD8COVISHIELD™heterologous responsesneutralizing antibodySARS-CoV-2trained immunity

Identifiers

PMID35262071
PMCPMC8902867

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.