SynthesisPeerJ2022
Titanium dioxide dental implants surfaces related oxidative stress in bone remodeling: a systematic review.
Synthesis in PeerJ, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Nano-warfare in the oral cavity: antimicrobial strategies and mechanisms in nanodentistry.Odontology · 2026Review
- Beyond the germ: Rethinking implant-related infections as a host-microbiota-biomaterial ecosystem.Biofilm · 2026Review
- Combined exposure to titanium nanoparticles and nanoplastics damages the male reproductive system and sperm activity.Materials today. Bio · 2026Article
- Biofilms and oral health: nanotechnology for biofilm control.Discover nano · 2025Review
- Evaluating Biocompatibility: From Classical Techniques to State-of-the-Art Functional Proteomics.Nanomaterials (Basel, Switzerland) · 2025Review
- Impact of Titanium Plate Fixation on Diacylglycerol and Growth Factor Levels in the Periosteum of the Mandible and Maxilla in Patients with Dentofacial Deformities After Jaw Osteotomies.International journal of molecular sciences · 2025Article
- Peri-implant diseases triggered by oral microdysbiosis: pathogenesis and precision intervention strategies.Frontiers in microbiology · 2025Review
- Potential role of metal nanoparticles in treatment of peri-implant mucositis and peri-implantitis.Biomedical engineering online · 2024Review
- Application of nanoparticles as surface modifiers of dental implants for revascularization/regeneration of bone.BMC oral health · 2024Review
- Investigating the influence of titanium particle size and concentration on osteogenic response of human osteoblasts - in vitro study.Biomaterial investigations in dentistry · 2024Article
- Inflammatory, Oxidative Stress and Small Cellular Particle Response in HUVEC Induced by Debris from Endoprosthesis Processing.Materials (Basel, Switzerland) · 2023Article
- Bioactivity, Molecular Mechanism, and Targeted Delivery of Flavonoids for Bone Loss.Nutrients · 2023Review
- Applications of Antioxidants in Dental Procedures.Antioxidants (Basel, Switzerland) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Titanium dioxide dental implants have a controversial effect on reactive oxygen species (ROS) production. ROS is necessary for cellular signal transmission and proper metabolism, but also has the ability to cause cell death as well as DNA, RNA, and proteins damage by excessive oxidative stress. This study aimed to systematically review the effect of titanium dioxide dental implant-induced oxidative stress and its role on the osteogenesis-angiogenesis coupling in bone remodeling. Methods: This systematic review was performed conforming to preferred reporting items for systematic review and meta-analysis (PRISMA) model. Four different databases (PubMed, Science Direct, Scopus and Medline databases) as well as manual searching were adopted. Relevant studies from January 2000 till September 2021 were retrieved. Critical Appraisal Skills Programme (CASP) was used to assess the quality of the selected studies. Results: Out of 755 articles, only 14 which met the eligibility criteria were included. Six studies found that titanium dioxide nanotube (TNT) reduced oxidative stress and promoted osteoblastic activity through its effect on Wnt, mitogen-activated protein kinase (MAPK) and forkhead box protein O1 (FoxO1) signaling pathways. On the other hand, three studies confirmed that titanium dioxide nanoparticles (TiO Conclusion: TiO
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.