ArticleAmerican journal of cancer research2022
Socioeconomic deprivation and survival outcomes in patients with colorectal cancer.
Article in American journal of cancer research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Area-level socioeconomic status is associated with colorectal cancer screening, incidence and mortality in the US: a systematic review and meta-analysis.Social science & medicine (1982) · 2025Pooled it
- Associations of neighborhood deprivation with breast cancer tumor genomics, targeted treatment use, and survival.Breast cancer research and treatment · 2026Observational
- The effects of socioeconomic deprivation on colorectal cancer outcomes; a retrospective regional cohort study.International journal of colorectal disease · 2026Article
- Interrogating the Mechanistic Link between Neighborhood Deprivation and Colorectal Cancer Risk through Transcriptomic Analysis of Normal Colorectal Biopsies.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- Cancer Burden in Persistent Poverty Areas across the Cancer Continuum: A Scoping Review to Identify Gaps and Opportunities for Future Research.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- Neighborhood-level socioeconomic disadvantage is associated with gut microbial composition and diversity across many chronic disease states.Frontiers in public health · 2026Article
- Article
- Neighborhood Disadvantage and Cardiovascular Mortality Among Colorectal Cancer Survivors.Cancers · 2025Article
- Effect of Socioeconomic Status on Financial Toxicity: The Chain Mediating Roles of Social Support and Self-Efficacy.Cancer medicine · 2025Article
- Social-Environmental Burden Is Associated with Increased Colorectal Cancer Mortality in Metropolitan Detroit.Cancer research communications · 2025Article
- Area Socioeconomic Status and Early Onset Rectal Cancer in a Comprehensive Cancer Center: Evidence from Wisconsin.WMJ : official publication of the State Medical Society of Wisconsin · 2025Article
- Increased accrual of diverse patient populations in oncology phase I clinical trials at the University of Colorado Cancer Center.Frontiers in oncology · 2025Article
- Neighborhood Disadvantage and Prostate Tumor Aggressiveness among African American and European American Men.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Epidemiology and risk factors for adult gliomas died by respiratory diseases during the COVID-19 pandemic: a population-based study.Neurosurgical review · 2024Article
- Racial Disparities in Receipt of Guideline-Concordant Care for Early-Onset Colorectal Cancer: We Must Do Better.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024Article
- Racial disparities in the relationship of regional socioeconomic status and colorectal cancer survival in the five regions of Georgia.Cancer medicine · 2024Article
- Unlocking Early Cancer Detection: Exploring Biomarkers, Circulating DNA, and Innovative Technological Approaches.Cureus · 2023Review
- Article
- Neighborhood-Level Socioeconomic Disadvantage Predicts Outcomes in Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Malignancy.Annals of surgical oncology · 2023Article
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Socioeconomic deprivation has been linked to detrimental healthcare outcomes. We sought to examine whether patients with colorectal cancer (CRC) from socioeconomically disadvantaged areas experience worse survival outcomes and how it interacts with other factors. In this population-based study, patients with CRC diagnosed between 2007 to 2015 in the SEER program were reviewed. Socioeconomic deprivation was measured using the Area Deprivation Index (ADI) linked to patients' residence addresses. The effect of ADI on cancer-specific survival and overall survival was evaluated using survival analysis. The Inverse Probability of Weighted (IPW) method and multiple regression was performed to account for the confounding bias. Subgroup analyses were used to test interactions. Multiple mediation analysis was used to estimate the mediating effects. Overall, 266,620 eligible patients were included in further analyses. Compared with low ADI patients, high ADI patients had more unfavorable characteristics and worse cancer-specific (hazard ratio [HR] 1.14, 95% CI 1.12-1.16, P<.001) and overall survival (HR 1.11, 95% CI 1.09-1.12, P<0.001). The results were similar after accounting for confounding factors using the IPW and multiple regression methods. Subgroup analyses revealed the relative robustness of ADI as a prognostic factor. They detected significant interactions between ADI and other covariates on cancer survival, such as age, race, insurance status, disease stage, and receipt of treatment. Multiple mediation analyses identified several factors mediating survival disparities, including anticancer therapy, insurance status, race, marital status, and age. This study suggested that high ADI CRC patients were associated with more unfavorable characteristics at presentation and lower cancer and noncancer survival after treatment than their low ADI counterparts. Multiple factors interacted and mediated these survival disparities associated with the ADI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.