Evidence map›Paper›PMID 35261799›Full record

ArticleAmerican journal of cancer research2022

APOBEC3F expression in triple-negative breast cancer is associated with tumor microenvironment infiltration and activation of cancer immunity and improved survival.

Rongrong Wu, Masanori Oshi, Mariko Asaoka, Michelle R Huyser, Yoshihisa Tokumaru, Akimitsu Yamada, Li Yan, Itaru Endo, Takashi Ishikawa, Kazuaki Takabe

Abstract read
In one paragraph

Article in American journal of cancer research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. The immunology of human breast cancer.Nature reviews. Immunology · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. APOBEC3B expression has prognostic significance in cervical cancer.International journal of clinical and experimental pathology · 2023
    Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rongrong WuDepartment of Surgical Oncology, Roswell Park Cancer Institute Buffalo, NY, USA.
Masanori OshiDepartment of Surgical Oncology, Roswell Park Cancer Institute Buffalo, NY, USA.
Mariko AsaokaDepartment of Surgical Oncology, Roswell Park Cancer Institute Buffalo, NY, USA.
Michelle R HuyserDepartment of Surgical Oncology, Roswell Park Cancer Institute Buffalo, NY, USA.
Yoshihisa TokumaruDepartment of Surgical Oncology, Roswell Park Cancer Institute Buffalo, NY, USA.
Akimitsu YamadaDepartment of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine Yokohama, Kanagawa, Japan.
Li YanDepartment of Biostatistics & Bioinformatics, Roswell Park Cancer Institute Buffalo, NY, USA.
Itaru EndoDepartment of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine Yokohama, Kanagawa, Japan.
Takashi IshikawaDepartment of Breast Surgery and Oncology, Tokyo Medical University Tokyo, Japan.
Kazuaki TakabeDepartment of Surgical Oncology, Roswell Park Cancer Institute Buffalo, NY, USA.

Funding

Impact of Circulating Myeloid Cell Clusters on Anti-Tumor ImmunityR01CA250412 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI ABRAMS, SCOTT I., EVANS, SHARON S · 2021 to 2025
$3.4M
Functional Significance of individual p53 mutations in determining the role of estrogen receptor beta in triple negative breast cancerR01CA251545 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI DAS, GOKUL M. · 2021 to 2025
$2.9M
Leveraging the GTP Biosynthetic Pathway for Anti-Tumor TherapiesR37CA248018 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI Anna Bianchi-Smiraglia · 2021 to 2026
$2.3M
NCI NIH HHS R01 CA250412NCI NIH HHS R01 CA251545NCI NIH HHS R37 CA248018
6 · The paper itself

Abstract

The apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC) causes a point mutation from cytidine to uracil in DNA and/or RNA. The role of APOBEC3A and APOBEC3B in breast cancer has been well described, whereas that of APOBEC3F remains unknown. To investigate the clinical relevance of APOBEC3F expression, we analyzed a total of 3000 breast cancer cases from multiple independent large patient cohorts including METABRIC, TCGA, GSE75688, and GSE114725. High expression of

Indexed as

APOBECAPOBEC3FGSEAimmune cellimmune check pointsingle-cell sequencingtriple negative breast cancertumor microenvironmentxCell

Identifiers

PMID35261799
PMCPMC8899983

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.