Evidence map›Paper›PMID 35261638›Full record

ReviewOncology letters2022

Anticoagulation for atrial fibrillation in active cancer.

Dimitrios Farmakis, Pavlos Papakotoulas, Eleni Angelopoulou, Theodoros Bischiniotis, George Giannakoulas, Panagiotis Kliridis, Dimitrios Richter, Ioannis Paraskevaidis

Open access · diamondAbstract readReview
In one paragraph

Review in Oncology letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Cancer, Inflammation, and Thrombosis: Drivers of Atrial Fibrillation in Oncology Patients.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 2 countries.

Dimitrios FarmakisDepartment of Physiology, University of Cyprus Medical School, Nicosia 2029, Cyprus.
Pavlos PapakotoulasFirst Department of Clinical Oncology, 'Theagenio' Anticancer Hospital, Thessaloniki 546 39, Greece.
Eleni AngelopoulouDepartment of Cardiology, 'Agioi Anargyroi' General Oncology Hospital, Athens 145 64, Greece.
Theodoros BischiniotisDepartment of Cardiology, 'Theagenio' Anticancer Hospital, Thessaloniki 546 39, Greece.
George GiannakoulasDepartment of Cardiology, AHEPA General Hospital, Aristotle University of Thessaloniki, Thessaloniki 546 21, Greece.
Panagiotis KliridisDepartment of Cardiology, 'Agios Savvas' General Anti-Cancer Hospital, Athens 115 22, Greece.
Dimitrios RichterDepartment of Cardiology, Athens Euroclinic, Athens 115 21, Greece.
Ioannis ParaskevaidisDepartment of Therapeutics, 'Alexandra' General Hospital, National and Kapodistrian University of Athens Medical School, Athens 115 28, Greece.
Theageneio General Hospital · GRAHEPA University Hospital · GRAlexandra Hospital · GRAthens Euroclinic · GRHospital Agioi Anargyroi · GRSt Savas Hospital · GRUniversity of Cyprus · CY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atrial fibrillation (AF) may often pre-exist in patients with newly diagnosed cancer or occur with increased frequency shortly after cancer diagnosis. Patients with active cancer and AF have a particularly high risk of thromboembolic complications, as both conditions carry a risk of thrombosis. Thromboembolic risk is determined by several factors, including advanced age, sex (females), cancer histology (adenocarcinomas), location (e.g., pancreas, stomach), advanced stage, anticancer regimens (e.g., platinum compounds, anti-angiogenic therapies, immune modulators), comorbidities (e.g., obesity, kidney disease) and concurrent therapies (e.g., surgery, central catheters). Physicians are often reluctant to prescribe anticoagulants to patients with active cancer and AF, mainly due to fear of bleeding complications, which is partly related to the paucity of evidence in the field. Decision making regarding anticoagulation for the prevention of ischemic stroke and systemic embolism in patients with active cancer and AF may be challenging and should not simply rely on the risk prediction scores used in the general AF population. By contrast, the administration and choice of anticoagulants should be based on the comprehensive, individualized and periodic evaluation of thromboembolic and bleeding risk, drug-drug interactions, patient preferences and access to therapies.

Indexed as

anticoagulationatrial fibrillationcancerdirect oral anticoagulantslow molecular weight heparins

Identifiers

PMID35261638
PMCPMC8867206
OpenAlexW4213347228

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.