Evidence map›Paper›PMID 35261337›Full record

ArticleeLife2022

Ecdysone coordinates plastic growth with robust pattern in the developing wing.

André Nogueira Alves, Marisa Mateus Oliveira, Takashi Koyama, Alexander Shingleton, Christen Kerry Mirth

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. NFYB Integrates Hormonal Signals into Tissue Allometry by Promoting Protein Biosynthesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
  3. bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Article
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  7. A dynamical model of growth and maturation inProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  8. Article
  9. Article
  10. Review
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 4 countries.

André Nogueira Alves *Instituto Gulbenkian de Ciência, Oeiras, Portugal.
Marisa Mateus Oliveira *Instituto Gulbenkian de Ciência, Oeiras, Portugal.
Takashi KoyamaInstituto Gulbenkian de Ciência, Oeiras, Portugal.ORCID 0000-0003-4203-114X
Alexander Shingleton *Department of Biological Sciences, University of Illinois at Chicago, Chicago, United States.ORCID 0000-0001-9862-9947
Christen Kerry Mirth *Instituto Gulbenkian de Ciência, Oeiras, Portugal.ORCID 0000-0002-9765-4021
Instituto Gulbenkian de Ciência · PTUniversity of Copenhagen · DKUniversity of Illinois Chicago · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Animals develop in unpredictable, variable environments. In response to environmental change, some aspects of development adjust to generate plastic phenotypes. Other aspects of development, however, are buffered against environmental change to produce robust phenotypes. How organ development is coordinated to accommodate both plastic and robust developmental responses is poorly understood. Here, we demonstrate that the steroid hormone ecdysone coordinates both plasticity of organ size and robustness of organ pattern in the developing wings of the fruit fly

Indexed as

Drosophila ProteinsEcdysoneAnimalsDrosophilaDrosophila melanogasterGene Expression Regulation, DevelopmentalLarvaPlasticsSignal TransductionDrosophila ProteinsEcdysonePlasticsdevelopmental biologydevelopmental robustnessD. melanogasterevolutionary biologygrowth ratespatterning ratesphenotypic plasticitywing disc

Identifiers

PMID35261337
PMCPMC8947767
OpenAlexW4225898669

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.