ArticleJournal of the American Heart Association2022
Prevalence, Predictors, Progression, and Prognosis of Hypertension Subtypes in the Framingham Heart Study.
Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- Isolated Diastolic Hypertension and Cardiovascular Disease Risk in Young Adults.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Acute effect of isometric wall squat on hemodynamic and autonomic status according to hypertensive subtypes in adults.European journal of applied physiology · 2026Article
- Insights Into Cardiovascular Disease in Women From the Framingham Heart Study.JACC. Advances · 2026Article
- Development and Temporal Validation of a Multinomial Prediction Model for Phenotypes of Undiagnosed Hypertension in Peru: A Population-Based Study.Medical sciences (Basel, Switzerland) · 2026Article
- Hypertension Subtypes and Diabetes: Joint Associations in the National Health and Nutrition Examination Survey.JACC. Advances · 2026Article
- Alcohol Consumption Patterns and Traditional Beverages Associated with Hypertension Subtypes.Medical sciences (Basel, Switzerland) · 2026Article
- Mortality trends in isolated systolic, diastolic, and combined hypertension: insights from NHANES database.Clinical hypertension · 2026Article
- Hyperdynamic circulation distinguishes predominantly diastolic hypertension from predominantly systolic hypertension.Journal of human hypertension · 2025Article
- Adverse Cardiovascular Events Are Infrequent but Significantly Associated With Systolic and Pre-Systolic Hypertension: An Occupational Cohort Study.Cardiology research · 2025Article
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- Associations of triglyceride-glucose index and metabolic score for insulin resistance with various hypertension phenotypes in children and adolescents: results from the 2017 China nutrition and health surveillance.Frontiers in endocrinology · 2025Article
- [Prevalence and Influencing Factors of Isolated Diastolic Hypertension in Tibetan Population in Tibet].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Article
- 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2024Review
- Prognostic nutritional index as a predictor of cardiovascular and all-cause mortality in American adults with hypertension: results from the NHANES database.Frontiers in cardiovascular medicine · 2024Article
- Hemodynamic profiles of arterial hypertension with ambulatory blood pressure monitoring.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
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5 authors at 1 institution in 1 country.
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Abstract
Background The epidemiology of hypertension subtypes has not been well characterized in the recent era. Methods and Results We delineated the prevalence, predictors, progression, and prognostic significance of hypertension subtypes in 8198 Framingham Heart Study participants (mean age, 46.5 years; 54% women). The prevalence of hypertension subtypes was as follows: nonhypertensive (systolic blood pressure [SBP] <140 mm Hg and diastolic blood pressure [DBP] <90 mm Hg), 79%; isolated systolic hypertension (ISH; SBP ≥140 mm Hg and DBP <90 mm Hg), 8%; isolated diastolic hypertension (SBP <140 mm Hg and DBP ≥90 mm Hg), 4%; and systolic-diastolic hypertension (SDH; SBP ≥140 mm Hg and DBP ≥90 mm Hg), 9%. The prevalence of ISH and SDH increased with age. Analysis of a subsample of nonhypertensive participants demonstrated that increasing age, female sex, higher heart rate, left ventricular mass, and greater left ventricular concentricity were predictors of incident ISH and SDH. Higher baseline DBP was associated with the risk of developing isolated diastolic hypertension and SDH, whereas higher SBP was associated with all 3 hypertension subtypes. On follow-up (median, 5.5 years), isolated diastolic hypertension often reverted to nonhypertensive BP (in 42% of participants) and ISH progressed to SDH (in 26% of participants), whereas SDH frequently transitioned to ISH (in 20% of participants). During follow-up (median, 14.6 years), 889 participants developed cardiovascular disease. Compared with the nonhypertensive group (referent), ISH (adjusted hazard ratio [HR], 1.57; 95% CI, 1.30-1.90) and SDH (HR, 1.66; 95% CI, 1.36-2.01) were associated with increased cardiovascular disease risk, whereas isolated diastolic hypertension was not (HR, 1.03; 95% CI, 0.68-1.57). Conclusions Hypertension subtypes vary in prevalence with age, are dynamic during short-term follow-up, and exhibit distinctive prognoses, underscoring the importance of blood pressure subphenotyping.
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