ReviewJournal of Zhejiang University. Science. B2022
Modification of polyetheretherketone (PEEK) physical features to improve osteointegration.
Review in Journal of Zhejiang University. Science. B, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- [Short-term safety and effectiveness of domestic polyether-ether-ketone suture anchors for rotator cuff repair: A multicenter, randomized, single-blind, parallel-controlled noninferiority study].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2022Trial
- Network Toxicology and Molecular Docking Analysis of Targets and Potential Mechanisms of PEEK-Induced Bone Resorption.International journal of molecular sciences · 2026Article
- Role of polyetheretherketone (PEEK) in arthroplasty and orthopaedics: a review of biomechanical properties, surface modifications, and clinical outcomes.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Review
- Bioinspired functional materials for biomedical applications.Frontiers in bioengineering and biotechnology · 2026Review
- Polyetheretherketone for craniomaxillofacial defects: cases report, evaluation of patients' satisfaction and a systematic literature review.Maxillofacial plastic and reconstructive surgery · 2025Article
- Review
- Effects of surface treatments on the adhesion strengths between polyether ether ketone and both composite resins and poly(methyl methacrylate).BMC oral health · 2025Article
- Mandibular Angle Osteotomy via Intraoral Approach: A 15-Year Experience from a Single Plastic Surgery Center in China.Aesthetic plastic surgery · 2025Article
- [Research progress on enhancing osseointegration properties of polyetheretherketone implants through various modification methods].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025Review
- Polydopamine grafting polyether ether ketone to stabilize growth factor for efficient osteonecrosis repair.Scientific reports · 2025Article
- Metal semiconductor materials in bone diseases: properties, applications, and future perspectives.Burns & trauma · 2025Review
- 3D-printed PEEK versus conventional free fibula flap for jaw reconstruction: a comparative clinical study.Frontiers in oncology · 2025Article
- Revolutionizing Dental Polymers: The Versatility and Future Potential of Polyetheretherketone in Restorative Dentistry.Polymers · 2024Review
- Bone Regeneration and Polyetheretherketone Implants in Maxillo-Facial Surgery and Neurosurgery: A Multidisciplinary Study.Biology · 2024Article
- Review
- Fundamentals of Mechanobiology and Potential Applications in Spinal Fusion.International journal of spine surgery · 2023Article
- Bioactive Polyetheretherketone with Gelatin Hydrogel Leads to Sustained Release of Bone Morphogenetic Protein-2 and Promotes Osteogenic Differentiation.International journal of molecular sciences · 2023Article
- Article
- Near-Surface Nanomechanics of Medical-Grade PEEK Measured by Atomic Force Microscopy.Polymers · 2023Article
- State-of-the-art polyetheretherketone three-dimensional printing and multifunctional modification for dental implants.Frontiers in bioengineering and biotechnology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyetheretherketone (PEEK) has been widely applied in orthopedics because of its excellent mechanical properties, radiolucency, and biocompatibility. However, the bioinertness and poor osteointegration of PEEK have greatly limited its further application. Growing evidence proves that physical factors of implants, including their architecture, surface morphology, stiffness, and mechanical stimulation, matter as much as the composition of their surface chemistry. This review focuses on the multiple strategies for the physical modification of PEEK implants through adjusting their architecture, surface morphology, and stiffness. Many research findings show that transforming the architecture and incorporating reinforcing fillers into PEEK can affect both its mechanical strength and cellular responses. Modified PEEK surfaces at the macro scale and micro/nano scale have positive effects on cell-substrate interactions. More investigations are necessary to reach consensus on the optimal design of PEEK implants and to explore the efficiency of various functional implant surfaces. Soft-tissue integration has been ignored, though evidence shows that physical modifications also improve the adhesion of soft tissue. In the future, ideal PEEK implants should have a desirable topological structure with better surface hydrophilicity and optimum surface chemistry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.