ArticleAutism research : official journal of the International Society for Autism Research2022
Prenatal exposure to pesticide residues in the diet in association with child autism-related traits: Results from the EARLI study.
Article in Autism research : official journal of the International Society for Autism Research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Investigating the role of food pollutants in autism spectrum disorder: a comprehensive analysis of heavy metals, pesticides, and mycotoxins.Naunyn-Schmiedeberg's archives of pharmacology · 2025Pooled it
- Environmental pollutants as risk factors for autism spectrum disorders: a systematic review and meta-analysis of cohort studies.BMC public health · 2024Pooled it
- Maternal Prenatal Supplements Intake and Dietary Sources and Their Relation to Autism Spectrum Disorder in the Population of Bangladesh.Public health challenges · 2026Article
- Impact of maternal microbiota imbalance during pregnancy on fetal cerebral neurodevelopment: Is there a link to certain autistic disorders?Brain, behavior, & immunity - health · 2025Review
- Testing the Development of a Diet-Based Bisphenol a Score to Facilitate Studies on Child Neurodevelopment: A Pilot Project.International journal of environmental research and public health · 2025Article
- Professionally and non-professionally applied household insecticides during pregnancy and early life and their associations with autism spectrum disorder and developmental delay in the CHARGE case-control study.Environmental research · 2025Article
- Examining Prenatal Dietary Factors in Association with Child Autism-Related Traits Using a Bayesian Mixture Approach: Results from 2 United States Cohorts.Current developments in nutrition · 2023Article
- Maternal Dietary Patterns during Pregnancy and Child Autism-Related Traits: Results from Two US Cohorts.Nutrients · 2022Article
- Prenatal exposure to pesticide residues in the diet in association with child autism-related traits: Results from the EARLI study.Autism research : official journal of the International Society for Autism Research · 2022Article
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11 authors at 6 institutions in 1 country.
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Abstract
Prior work has suggested associations between prenatal exposure to several classes of pesticides and child autism spectrum disorder (ASD). We examined a previously developed pesticide residue burden score (PRBS) and intake of high pesticide residue foods in association with ASD-related traits. Participants were drawn from the Early Autism Risk Longitudinal Investigation (EARLI) (n = 256), a cohort following mothers who previously had a child with ASD through a subsequent pregnancy and that child's development. ASD-related traits were captured according to total Social Responsiveness Scale (SRS) scores at age 3 (mean raw total SRS score = 35.8). Dietary intake was assessed through a food frequency questionnaire collected during pregnancy. We also incorporated organic intake and fatty foods in modified versions of the PRBS. Associations between high-residue fruit and vegetable intake, the overall PRBS and modified versions of it, and SRS scores were assessed using multivariable linear regression. Overall, we did not observe associations between pesticide residues in foods and ASD-related outcomes, and modified versions of the PRBS yielded similar findings. However, reductions in ASD-related traits were observed with higher overall fruit and vegetable intake (adjusted estimates for Q4 vs. Q1: β -12.76, 95%CI -27.8, 2.3). Thus, findings from this high familial probability cohort did not suggest relationships between pesticide residues in the diet according to the PRBS and ASD-related traits. Beneficial effects of fruit and vegetable intake may influence these relationships. Future work should consider fruit and vegetable intake in association with ASD-related outcomes. LAY SUMMARY: Diet is the main source of exposure to most pesticides in use today. In this study, we examined the relationship between pesticide exposure from residues in the diet during pregnancy and child autism-related traits. We found that these pesticide residues from the diet were not related to child autism-related outcomes at age three. However, higher prenatal fruit and vegetable intake was associated with reductions in child autism-related traits.
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