Evidence map›Paper›PMID 35261118›Full record

ArticleDermatologic therapy2022

Neonatal ischemic limb lesions: From etiology to topical nitroglycerine. A case series analysis.

Raffaele Falsaperla, Manuela Lo Bianco, Andrea Giugno, Germana Lena, Laura Sciuto, Francesco Spata, Claudio Guarneri, Piero Pavone, Martino Ruggieri

Abstract read
In one paragraph

Article in Dermatologic therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Raffaele FalsaperlaGeneral Pediatrics and Pediatric Acute and Emergency Unit, Policlinico "G. Rodolico-San Marco" University Hospital, University of Catania, Catania, Italy.
Manuela Lo BiancoPost Graduate Programme in Paediatrics, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.ORCID 0000-0002-5413-419X
Andrea GiugnoPost Graduate Programme in Paediatrics, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Germana LenaPost Graduate Programme in Paediatrics, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Laura SciutoPost Graduate Programme in Paediatrics, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Francesco SpataNeonatal Intensive Care Unit, "Giovanni Paolo II" Hospital, Ragusa, Italy.
Claudio GuarneriDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, Section of Dermatology, A.O.U.P. "Gaetano Martino", University of Messina, Messina, Italy.
Piero PavoneDepartment of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, University of Catania, Catania, Italy.ORCID 0000-0002-5600-9560
Martino RuggieriUnit of Rare Diseases of the Nervous System in Childhood, Department of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, University of Catania, Catania, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although rare, ischemic lesions in neonates may occur in Neonatal Intensive Care Units (NICUs) secondary to routine procedures and/or medicaments. We present double-center case series, reporting three preterm neonates with ischemic lesions following cardiac arrest and radial blood sampling. The overall outcome after treatment with 2% nitroglycerine (NTG) ointment showed optimal results with no adverse events. The most frequent causes responsible for the onset of such lesions are peripheral arterial catheterization procedures and dopamine extravasation. Our series describe the cardiac arrest as an underestimated cause of onset. Despite the optimal results emerging from the treatment of such lesions with NTG ointment, both in our experience and in the scientific literature, a defined protocol for its use in NICUs is not currently available, hence the need for further studies.

Indexed as

Heart ArrestIntensive Care Units, NeonatalHumansInfant, NewbornOintmentsOintmentsischemic lesionsnewbornNICUsnitroglycerineside effects

Identifiers

PMID35261118
PMCPMC9286834

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.