Trial reportHuman brain mapping2022
The causal role of the bilateral ventrolateral prefrontal cortices on emotion regulation of social feedback.
Trial report in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- The medial prefrontal cortex as a proposed regulatory structure in the relationship between anxiety and perceived social support: a review.BMC psychology · 2025Pooled it
- A simple alternative to nondeceptive placebos for reducing emotional distress: encouragement.Social cognitive and affective neuroscience · 2025Trial
- The role of ventrolateral prefrontal cortex on voluntary emotion regulation of social pain.Human brain mapping · 2023Trial
- The causal role of the bilateral ventrolateral prefrontal cortices on emotion regulation of social feedback.Human brain mapping · 2022Trial
- A Critical Time Window of Neocortex Modulation for Remote Fear Memory in Rats and Humans.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Emotion regulation modulates subsequent control of unwanted memories.Social cognitive and affective neuroscience · 2026Article
- Is poor control over thoughts and emotions related to a higher tendency to delay tasks? The link between procrastination, emotional dysregulation and attentional control.British journal of psychology (London, England : 1953) · 2025Article
- Socially-Based Emotion Dysregulation Among Hearing-Impaired Adolescents: An Event-Related Potential Study.Brain and behavior · 2025Article
- Emotion Regulation Modulates Affective Responses Without Altering Memory Traces: A Study of Negative Social Feedback from Acquaintances.Behavioral sciences (Basel, Switzerland) · 2025Article
- Repeated theta burst stimulation of the right ventrolateral prefrontal cortex reveals strong habituation in the context of stress and rumination.Scientific reports · 2025Article
- Comparing the neural bases of self- and social-reappraisal.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- How Self-Involvement affects miners' safety risk Decision-Making: an ERP study.Scientific reports · 2025Article
- Article
- Neurocomputational mechanisms of personal benefits and justifications in moral decision-making.Communications biology · 2025Article
- Prefrontal-Dependent and Gender-Specific Modulation of Guilt Emotion on Human Early Visual Perception.Behavioral sciences (Basel, Switzerland) · 2025Article
- Attenuation processes in positive social emotion upregulation: Disentangling functional role of ventrolateral prefrontal cortex.iScience · 2025Article
- Scarcity mindset facilitates empathy for social pain and prosocial intention: behavioral and neural evidences.Social cognitive and affective neuroscience · 2025Article
- Targeting the dorsolateral prefrontal cortex to enhance memory control: divergent effects on social and non-social memories.Social cognitive and affective neuroscience · 2025Article
- The ventromedial prefrontal cortex plays an important role in implicit emotion regulation: A focality-optimized multichannel tDCS study in anxiety individuals.Human brain mapping · 2024Article
- Altered brain and physiological stress responses in early psychosis.Schizophrenia research · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ventrolateral prefrontal cortices (VLPFC) are crucial regions involved in voluntary emotion regulation. However, the lateralization of the VLPFC in downregulating negative emotions remains unclear; and whether the causal role of the VLPFC is generalizable to upregulating positive emotions is unexplored. This study used transcranial magnetic stimulation (TMS) to examine the causal relationship between the left/right VLPFC and social emotion reappraisal. One hundred and twenty participants were randomly assigned to either active (left and right VLPFC groups, n = 40/40) or sham (vertex, n = 40) TMS groups. Participants were instructed to passively receive social feedback or use reappraisal strategies to positively regulate their emotions. While the subjective emotional rating showed that the bilateral VLPFC facilitated the reappraisal success, the electrophysiological measure of the late positive potential (LPP) demonstrated a more critical role of the right VLPFC on social pain relief (decreased LPP amplitudes) and social reward magnification (enhanced LPP amplitudes). In addition, the influence of emotion regulation on social evaluation was found to be mediated by the memory of social feedback, indicating the importance of memory in social behavioral shaping. These findings suggest clinical protocols for the rehabilitation of emotion-regulatory function in patients with affective and social disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.