Evidence map›Paper›PMID 35260928›Full record

ArticleLasers in medical science2022

Hematoporphyrin monomethyl ether mediated photodynamic therapy inhibits oral squamous cell carcinoma by regulating the P53-miR-21-PDCD4 axis via singlet oxygen.

Peisong Meng, Yi Sun, Enze Li, Yunqing Liu, Cuiping Wang, Liping Song

Abstract read
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In one paragraph

Article in Lasers in medical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Peisong MengDepartment of Radiation, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
Yi SunDepartment of Stomatology, The Fourth Clinical Medical College of Harbin Medical University, Harbin, China.
Enze LiLaboratory of Sono-and Photo-Theranostic Technologies, Harbin Institute of Technology, Harbin, China.
Yunqing LiuDepartment of Restorative Dentistry, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan.
Cuiping WangDepartment of Stomatology, The Fourth Clinical Medical College of Harbin Medical University, Harbin, China.
Liping SongDepartment of Radiation, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China. songliping0029@126.com.
First Affiliated Hospital of Xi'an Jiaotong University · CNHarbin Medical University · CNHarbin Institute of Technology · CNHokkaido University · JP

Funding

Technological Innovation Projects of Harbin Municipal Science and Technology Bureau 2014RFXGJ095
6 · The paper itself

Abstract

The objective of this study was to determine the mechanism and effect of hematoporphyrin monomethyl ether mediated photodynamic therapy (HMME-PDT) on oral squamous cell carcinoma (OSCC). Human OSCC CAL-27 cells were randomly divided into four groups: control group, HMME group, laser group, and HMME-PDT group. Cell viability was detected by the CCK-8 method. Cell cycle distribution was evaluated by flow cytometry. GEO database was used to screen differentially expressed microRNAs (DEMs), and TCGA database was performed to verify DEM expression in OSCC and normal tissues. The effects of HMME-PDT on DEM expression were assayed by real-time PCR, and the expressions of miRNAs target genes were measured by western blot. Fluorescence probes were used to determine the production of singlet oxygen (

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsMicroRNAsMouth NeoplasmsPhotochemotherapyApoptosisApoptosis Regulatory ProteinsCell Line, TumorGPI-Linked ProteinsHematoporphyrinsHumansIntracellular Signaling Peptides and ProteinsMembrane ProteinsPhotosensitizing AgentsRNA-Binding ProteinsSinglet OxygenApoptosis Regulatory ProteinsGPI-Linked Proteinshematoporphyrin monomethyl etherHematoporphyrinsIntracellular Signaling Peptides and ProteinsMembrane ProteinsMicroRNAsMIRN21 microRNA, humanPDCD4 protein, humanPhotosensitizing AgentsRECK protein, humanRNA-Binding ProteinsSinglet OxygenSPRY2 protein, humanTumor Suppressor Protein p53Hematoporphyrin monomethyl etherMicroRNA-21Oral squamous cell carcinomaPhotodynamic therapySinglet oxygen

Identifiers

PMID35260928
OpenAlexW4220843120

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.