Evidence map›Paper›PMID 35260890›Full record

ArticleJournal of cell science2022

Perilipins at a glance.

Charles P Najt, Mahima Devarajan, Douglas G Mashek

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cell science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Plin2 Coordinates Immune and Metabolic Reprogramming in Lacrimal Gland Aging.Investigative ophthalmology & visual science · 2025
    Article
  12. The C-terminal end of PLIN1 displays structural disorder.Biochemistry and biophysics reports · 2025
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Charles P NajtDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0001-6455-8810
Mahima DevarajanDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-6397-5791
Douglas G MashekDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0001-7033-3386
University of Minnesota · US

Funding

Training Grant: Functional Proteomics of AgingT32AG029796 · NIA · UNIVERSITY OF MINNESOTA · PI EDGAR A ARRIAGA, Douglas G Mashek · 2008 to 2026
$6.6M
MUFA-SIRT1 signaling as a central node regulating healthspanR01AG069768 · NIA · UNIVERSITY OF MINNESOTA · PI MASHEK, DOUGLAS G · 2020 to 2024
$1.9M
Regulation and consequences of hepatic lipid droplet catabolismR01DK114401 · NIDDK · UNIVERSITY OF MINNESOTA · PI MASHEK, DOUGLAS G · 2017 to 2020
$1.7M
Role of ATGL and lipid metabolism in healthspanR01AG055452 · NIA · UNIVERSITY OF MINNESOTA · PI MASHEK, DOUGLAS G · 2017 to 2021
$1.6M
Perilipin 5: Linking lipid droplets to nutrient sensing and healthy agingR00AG070104 · NIA · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Charles P Najt · 2024 to 2026
$711k
Perilipin 5: Linking lipid droplets to nutrient sensing and healthy agingK99AG070104 · NIA · UNIVERSITY OF MINNESOTA · PI NAJT, CHARLES P · 2021 to 2022
$205k
Investigating the Role of PLIN2 in SenescenceF30AG076322 · NIA · UNIVERSITY OF MINNESOTA · PI DEVARAJAN, MAHIMA · 2022 to 2025
$162k
NIA NIH HHS F30 AG076322NIA NIH HHS K99 AG070104NIA NIH HHS R00 AG070104NIA NIH HHS R01 AG055452NIA NIH HHS R01 AG069768NIA NIH HHS T32 AG029796NIDDK NIH HHS R01 DK114401
6 · The paper itself

Abstract

Lipid droplets (LDs) are ubiquitous organelles that store and supply lipids for energy metabolism, membrane synthesis and production of lipid-derived signaling molecules. While compositional differences in the phospholipid monolayer or neutral lipid core of LDs impact their metabolism and function, the proteome of LDs has emerged as a major influencer in all aspects of LD biology. The perilipins (PLINs) are the most studied and abundant proteins residing on the LD surface. This Cell Science at a Glance and the accompanying poster summarize our current knowledge of the common and unique features of the mammalian PLIN family of proteins, the mechanisms through which they affect cell metabolism and signaling, and their links to disease.

Indexed as

Lipid DropletsPerilipinsAnimalsLipid MetabolismMammalsPhospholipidsProtein BindingProteomePerilipinsPhospholipidsProteomeLipid dropletsLipid metabolismLipid signalingPerilipins

Identifiers

PMID35260890
PMCPMC9014376
OpenAlexW4220831301

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.