ArticleNature neuroscience2022
Secondary auditory cortex mediates a sensorimotor mechanism for action timing.
Article in Nature neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Neural mechanisms of fear memory precision and generalization: from auditory cortex to amygdala.Translational psychiatry · 2026Review
- Optimizing exercise for brain health: cortical activation and connectivity across different exercise modalities.Brain structure & function · 2026Article
- A behavioral integration mechanism underlies action timing.Science advances · 2026Article
- Striatal Pathways for Action Counting and Steering.bioRxiv : the preprint server for biology · 2025Article
- An auditory cortical-striatal circuit supports sound-triggered timing to predict future events.PLoS biology · 2025Article
- The Role of Striatum in Controlling Waiting during Reactive and Self-Timed Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Abnormal Functional Connectivity of the Primary Sensory Network in Autism Spectrum Disorder: Sex Differences, Early Overdevelopment, and Clinical Significance.Brain and behavior · 2025Article
- Auditory discrimination learning differentially modulates neural representation in auditory cortex subregions and inter-areal connectivity.Cell reports · 2024Article
- The Interactions of Temporal and Sensory Representations in the Basal Ganglia.Advances in experimental medicine and biology · 2024Review
- Cognition of Time and Thinking Beyond.Advances in experimental medicine and biology · 2024Review
- A Cortico-Striatal Circuit for Sound-Triggered Prediction of Reward Timing.bioRxiv : the preprint server for biology · 2023Article
- Crossmodal plasticity in hearing loss.Trends in neurosciences · 2023Review
- Closing the loop on models of interval timing.Nature neuroscience · 2022Article
- Time Perception for Musical Rhythms: Sensorimotor Perspectives on Entrainment, Simulation, and Prediction.Frontiers in integrative neuroscience · 2022Review
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10 authors.
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Abstract
The ability to accurately determine when to perform an action is a fundamental brain function and vital to adaptive behavior. The behavioral mechanism and neural circuit for action timing, however, remain largely unknown. Using a new, self-paced action timing task in mice, we found that deprivation of auditory, but not somatosensory or visual input, disrupts learned action timing. The hearing effect was dependent on the auditory feedback derived from the animal's own actions, rather than passive environmental cues. Neuronal activity in the secondary auditory cortex was found to be both correlated with and necessary for the proper execution of learned action timing. Closed-loop, action-dependent optogenetic stimulation of the specific task-related neuronal population within the secondary auditory cortex rescued the key features of learned action timing under auditory deprivation. These results unveil a previously underappreciated sensorimotor mechanism in which the secondary auditory cortex transduces self-generated audiomotor feedback to control action timing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.