Evidence map›Paper›PMID 35260691›Full record

ArticleScientific reports2022

Evaluation of hepatitis C virus antibody assay using dried blood spot samples.

Vera Holzmayer, Russell Taylor, Mary C Kuhns, Susan H Gawel, Nicaise Ndembi, Dora Mbanya, Lazare Kaptue, Mary A Rodgers, Gavin Cloherty

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Vera HolzmayerAbbott Laboratories, Abbott Diagnostics Division, 100 Abbott Park Road, Bldg. AP20, Abbott Park, IL, 60064-3500, USA. vera.holzmayer@abbott.com.
Russell TaylorAbbott Laboratories, Abbott Diagnostics Division, 100 Abbott Park Road, Bldg. AP20, Abbott Park, IL, 60064-3500, USA.
Mary C KuhnsAbbott Laboratories, Abbott Diagnostics Division, 100 Abbott Park Road, Bldg. AP20, Abbott Park, IL, 60064-3500, USA.
Susan H GawelAbbott Laboratories, Abbott Diagnostics Division, 100 Abbott Park Road, Bldg. AP20, Abbott Park, IL, 60064-3500, USA.
Nicaise NdembiAfrica Centres for Disease Control and Prevention, Addis Ababa, Ethiopia.
Dora MbanyaUniversite de Yaounde I, Yaounde, Cameroon.
Lazare KaptueUniversite des Montagnes, Bangangte, Cameroon.
Mary A RodgersAbbott Laboratories, Abbott Diagnostics Division, 100 Abbott Park Road, Bldg. AP20, Abbott Park, IL, 60064-3500, USA.
Gavin ClohertyAbbott Laboratories, Abbott Diagnostics Division, 100 Abbott Park Road, Bldg. AP20, Abbott Park, IL, 60064-3500, USA.
Abbott Fund · USAfrica Centres for Disease Control and Prevention · ETUniversité des Montagnes · CMUniversité de Yaoundé I · CM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early diagnosis of hepatitis C virus (HCV) infection is essential for prompt initiation of treatment and prevention of transmission, yet several logistical barriers continue to limit access to HCV testing. Dried blood spot (DBS) technology involves a simple fingerstick that eliminates the need for trained personnel, and DBS can be stored and transported at room temperature. We evaluated the use of DBS whole blood samples in the modified Abbott ARCHITECT anti-HCV assay, comparing assay performance against the standard assay run using DBS and venous plasma samples. 144 HCV positive and 104 HCV negative matched venous plasma and whole blood specimens were selected from a retrospective study with convenience sampling in Cameroon. Results obtained using a modified volume DBS assay were highly correlated to the results of the standard assay run with plasma on clinical samples and dilution series (R

Indexed as

Hepatitis CHepatitis C AntibodiesDried Blood Spot TestingHepacivirusHumansRetrospective StudiesSensitivity and SpecificityHepatitis C Antibodies

Identifiers

PMID35260691
PMCPMC8904514
OpenAlexW4220811406

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.