Evidence map›Paper›PMID 35260587›Full record

ArticleScientific reports2022

BCL2A1 regulates Canady Helios Cold Plasma-induced cell death in triple-negative breast cancer.

Saravana R K Murthy, Xiaoqian Cheng, Taisen Zhuang, Lawan Ly, Olivia Jones, Giacomo Basadonna, Michael Keidar, Jerome Canady

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Saravana R K MurthyJerome Canady Research Institute for Advanced Biological and Technological Sciences, Takoma Park, MD, USA.
Xiaoqian ChengJerome Canady Research Institute for Advanced Biological and Technological Sciences, Takoma Park, MD, USA.
Taisen ZhuangPlasma Medicine Life Sciences, Takoma Park, MD, USA.
Lawan LyJerome Canady Research Institute for Advanced Biological and Technological Sciences, Takoma Park, MD, USA.
Olivia JonesJerome Canady Research Institute for Advanced Biological and Technological Sciences, Takoma Park, MD, USA.
Giacomo BasadonnaUniversity of Massachusetts School of Medicine, Worcester, MA, USA.
Michael KeidarThe George Washington University, Washington, DC, USA.
Jerome CanadyJerome Canady Research Institute for Advanced Biological and Technological Sciences, Takoma Park, MD, USA. drjcanady@jcri-abts.com.
George Washington University · USHoly Cross Hospital · USUniversity of Massachusetts Chan Medical School · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer is the leading cause of cancer death among women. Triple-negative breast cancer (TNBC) has a poor prognosis and frequently relapses early compared with other subtypes. The Cold Atmospheric Plasma (CAP) is a promising therapy for prognostically poor breast cancer such as TNBC. The Canady Helios Cold Plasma (CHCP) induces cell death in the TNBC cell line without thermal damage, however, the mechanism of cell death by CAP treatment is ambiguous and the mechanism of resistance to cell death in some subset of cells has not been addressed. We investigate the expression profile of 48 apoptotic and 35 oxidative gene markers after CHCP treatment in six different types of breast cancer cell lines including luminal A (ER

Indexed as

Breast NeoplasmsPlasma GasesTriple Negative Breast NeoplasmsCell DeathErb-b2 Receptor Tyrosine KinasesFemaleHumansNeoplasm Recurrence, LocalReceptors, EstrogenReceptors, ProgesteroneRNA, Small InterferingErb-b2 Receptor Tyrosine KinasesPlasma GasesReceptors, EstrogenReceptors, ProgesteroneRNA, Small Interfering

Identifiers

PMID35260587
PMCPMC8904455
OpenAlexW4220696897

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.